CAS 349085-82-1|GSK137647A

Introduction：Basic information about CAS 349085-82-1|GSK137647A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameGSK137647A
CAS Number349085-82-1Molecular Weight305.39200
Density/Boiling Point/
Molecular FormulaC16H19NO3SMelting Point/
MSDSChineseUSAFlash Point/

Names

Name4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
SynonymMore Synonyms

GSK137647A BiologicalActivity

DescriptionGSK137647A is a selective FFA4 agonist, with pEC50 of 6.3, 6.2, and 6.1 for human, Mouse and Rat FFA4, respectively.IC50 value: 6.3/6.2/6.1 (pEC50, for human/mouse/rat FFA4)Target: FFA4The pEC50s for Human , Mouse and Rat FFA1/2/3 are ＜ 4.5. GSK137647A is evaluated against a panel of 65 targets in both full curve functional and binding assays and was shown to provide at least 100-fold selectivity against the panel which included 41 G-protein-coupled receptors (GPCRs), including additional members of the free fatty acid receptors (FFA1, FFA2, and FFA3). GSK137647A produces a concentration-dependent increase in glucose stimulated insulin secretion under high glucose conditions (25 mM).
Related CatalogSignaling Pathways >>GPCR/G Protein >>GPR120Research Areas >>Metabolic Disease
References

[1]. Sparks SM, et al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3.

Chemical & Physical Properties

Molecular FormulaC16H19NO3S
Molecular Weight305.39200
Exact Mass305.10900
PSA63.78000
LogP4.57500
Appearance of Characterswhite solid
InChIKeyFQUAFMNPXPXOJE-UHFFFAOYSA-N
SMILESCOc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1
Storage condition-20℃

Safety Information

RIDADRNONH for all modes of transport

Synonyms

gsk 137647
GSK137647A
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