Introduction：Basic information about CAS 82209-74-3|19-hydroxy-8(17),13-labdadien-16,15-olide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 19-hydroxy-8(17),13-labdadien-16,15-olide |
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| CAS Number | 82209-74-3 | Molecular Weight | 318.45000 |
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| Density | 1.09 | Boiling Point | / |
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| Molecular Formula | C20H30O3 | Melting Point | 106-107ºC |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | 4-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
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| In Vitro | Andrograpanin exhibits anti-inflammatory properties in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways[1]. Andrograpanin enhances chemokine SDF-1α-induced leukocytes chemotaxis in Jurkat, THP-1 and PBL cells[2]. |
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| References | [1]. 1.Li-Li Ji, et al.Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis. J Cell Biochem. 2005 Aug 1;95(5):970-8. [2]. 2.Jun Liu, et al. Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways. Int Immunopharmacol. 2008 Jul;8(7):951-8. |
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Chemical & Physical Properties
| Density | 1.09 |
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| Melting Point | 106-107ºC |
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| Molecular Formula | C20H30O3 |
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| Molecular Weight | 318.45000 |
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| Exact Mass | 318.21900 |
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| PSA | 46.53000 |
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| LogP | 4.02100 |
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| InChIKey | WKKBRRFSRMDTJB-JYBIWHBTSA-N |
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| SMILES | C=C1CCC2C(C)(CO)CCCC2(C)C1CCC1=CCOC1=O |
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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Articles2
More Articles
| Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways. Int. Immunopharmacol. 8(7) , 951-8, (2008) Andrographis paniculata Nees is an official herbal medicine for treatment of infection and inflammation in China. Andrograpanin, the one of diterpene lactones in A. paniculata, is a hydrolysate from n... | |
| Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis. J. Cell. Biochem. 95(5) , 970-8, (2005) Andrographis paniculata is a traditional Chinese medicine (TCM) that has been effectively used for treatment of infection, inflammation, cold, fever, and diarrhea in China. However, mechanism of its t... | |
Synonyms
| 2(5H)-Furanone,3-(2-((1R,4aS,5R,8aS)-decahydro-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl) |
| UNII-89M92UDM18 |
| 3,14-Dideoxyandrographolide |
| 19-hydroxy-8(17),13-ent-labdadien-15->16 lactone |
| andrograpanin |
