CAS 929-59-9|ethylene glycol bis(2-aminoethyl) ether
| Common Name | ethylene glycol bis(2-aminoethyl) ether | ||
|---|---|---|---|
| CAS Number | 929-59-9 | Molecular Weight | 148.203 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 241.0±20.0 °C at 760 mmHg |
| Molecular Formula | C6H16N2O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 104.3±15.5 °C |
| Symbol | GHS05, GHS07, GHS08 | Signal Word | Danger |
Names
| Name | 1,8-Diamino-3,6-dioxaoctane |
|---|---|
| Synonym | More Synonyms |
ethylene glycol bis(2-aminoethyl) ether BiologicalActivity
| Description | PROTAC Linker 19 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 19 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl/ether |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 241.0±20.0 °C at 760 mmHg |
| Molecular Formula | C6H16N2O2 |
| Molecular Weight | 148.203 |
| Flash Point | 104.3±15.5 °C |
| Exact Mass | 148.121185 |
| PSA | 70.50000 |
| LogP | -1.59 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.460 |
| InChIKey | IWBOPFCKHIJFMS-UHFFFAOYSA-N |
| SMILES | NCCOCCOCCN |
Safety Information
| Symbol | GHS05, GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H314-H317-H334 |
| Precautionary Statements | P261-P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | C:Corrosive; |
| Risk Phrases | R22;R34;R42/43 |
| Safety Phrases | S23-S26-S36/37/39-S45 |
| RIDADR | UN 2735 8/PG 2 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2922199090 |
Customs
| HS Code | 2922199090 |
|---|---|
| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 2,2′-(ethylenedioxy)bis(ethylamine) |
| 1,8-diaminotriethyleneglycol |
| MFCD00040474 |
| 2,2'-[1,2-Ethanediylbis(oxy)]diethanamine |
| 2,2'-[ethane-1,2-diylbis(oxy)]diethanamine |
| 1,2-Bis(2-aminoethoxy)ethane |
| UNII-R41ZT4UF34 |
| Jeffamine® EDR-176 |
| EDR-148 |
| TRIETHYLENEGLYCOLDIAMINE |
| 1,8-Diamino-3,6-dioxaoctane |
| DA-10 |
| Jeffamine(R) EDR-176 |
| 2,2'-(Ethylenedioxy)bis(ethylamine) |
| 1,8-diamino-3,6-dioxa-octane |
| 3,6-dioxaoctamethylenediamine |
| Ethanamine, 2,2'-(1,2-ethanediylbis(oxy))bis- |
| 3,6-dioxa-1,8-octanediamine |
| EINECS 213-203-6 |
| Ethanamine, 2,2'-[1,2-ethanediylbis(oxy)]bis- |
| Jeffamine EDR-148 |
