CAS 472-11-7|Ruscogenin

Introduction：Basic information about CAS 472-11-7|Ruscogenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ruscogenin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Ruscogenin
CAS Number	472-11-7	Molecular Weight	430.62
Density	1.2±0.1 g/cm3	Boiling Point	563.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₇H₄₂O₄	Melting Point	198-202ºC
MSDS	ChineseUSA	Flash Point	294.4±30.1 °C

Names

Name	Ruscogenin
Synonym	More Synonyms

Ruscogenin BiologicalActivity

Description	Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>NOD-like Receptor (NLR)
References	[1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418. [2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.

Description

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].

Related Catalog

Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>NOD-like Receptor (NLR)

References

[1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418.

[2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	563.1±50.0 °C at 760 mmHg
Melting Point	198-202ºC
Molecular Formula	C₂₇H₄₂O₄
Molecular Weight	430.62
Flash Point	294.4±30.1 °C
Exact Mass	430.308319
PSA	58.92000
LogP	4.29
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.577
InChIKey	QMQIQBOGXYYATH-IDABPMKMSA-N
SMILES	CC1CCC2(OC1)OC1CC3C4CC=C5CC(O)CC(O)C5(C)C4CCC3(C)C1C2C
Storage condition	2~8℃

Safety Information

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	29389090

Synonyms

(1β,3β,25R)-Spirost-5-ene-1,3-diol

25D-Spirost-5-ene-1|A,3|A-diol

(25R)-Spirost-5-ene-1b,3b-diol

(25R)-Spirost-5-ene-1β,3β-diol

(1β,3β,25R)-Spirost-5-en-1,3-diol

Spirost-5-en-1,3-diol, (1β,3β,25R)-

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