CAS 34184-77-5|Promegestone

Introduction：Basic information about CAS 34184-77-5|Promegestone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Promegestone BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Synonyms

Common Name	Promegestone
CAS Number	34184-77-5	Molecular Weight	326.47200
Density	1.09 g/cm3	Boiling Point	486.8ºC at 760 mmHg
Molecular Formula	C₂₂H₃₀O₂	Melting Point	152°
MSDS	/	Flash Point	180.4ºC

Names

Name	promegestone
Synonym	More Synonyms

Promegestone BiologicalActivity

Description	Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research[1].
Related Catalog	Signaling Pathways >>Others >>Progesterone ReceptorResearch Areas >>CancerResearch Areas >>Endocrinology
In Vitro	Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC50 of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC50=1.93 nM)[1]. Promegestone is inactive in HELN cells that express luciferase but no functional receptor[1]. Promegestone (10 nM) robustly stimulates SLC37A2 expression in cells expressing SUMO-deficient PR, but not in cells expressing WT PR in T47D cell models[3].
In Vivo	Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth[2].
References	[1]. Clémentine Garoche, et al. Human and Zebrafish Nuclear Progesterone Receptors Are Differently Activated by Manifold Progestins. Environ Sci Technol. 2020 Aug 4;54(15):9510-9518. [2]. Michael A Kirby, et al. Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition. Reprod Sci. 2016 Nov;23(11):1473-1483. [3]. Todd P Knutson, et al. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol. 2017 Apr 17;10(1):89.

Chemical & Physical Properties

Density	1.09 g/cm3
Boiling Point	486.8ºC at 760 mmHg
Melting Point	152°
Molecular Formula	C₂₂H₃₀O₂
Molecular Weight	326.47200
Flash Point	180.4ºC
Exact Mass	326.22500
PSA	34.14000
LogP	5.17780
Index of Refraction	1.553
InChIKey	QFFCYTLOTYIJMR-XMGTWHOFSA-N
SMILES	CCC(=O)C1(C)CCC2C3CCC4=CC(=O)CCC4=C3CCC21C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG2965000

CHEMICAL NAME :: Estra-4,9-dien-3-one, 17-alpha-methyl-17-propionyl-

CAS REGISTRY NUMBER :: 34184-77-5

LAST UPDATED :: 199209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H30-O2

MOLECULAR WEIGHT :: 326.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 20 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 13,373,1992

Synonyms

R5020

(8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Promegestona

Promegestone

17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione

RU5020

Promegestonum

promegestrone

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