CAS 773-76-2|Chloroxine
Introduction：Basic information about CAS 773-76-2|Chloroxine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chloroxine | ||
|---|---|---|---|
| CAS Number | 773-76-2 | Molecular Weight | 214.048 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 354.7±37.0 °C at 760 mmHg |
| Molecular Formula | C9H5Cl2NO | Melting Point | 178-180 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 168.3±26.5 °C |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | chloroxine |
|---|---|
| Synonym | More Synonyms |
Chloroxine BiologicalActivity
| Description | Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.Target: AntibacterialChloroxine is an antibacterial drug. Oral formulations are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis, as used in shampoos and dermal creams like. Chloroxine has bacteriostatic, fungistatic and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella and Trichomonads. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
| References | [1]. http://www.drugs.com/cons/chloroxine-topical.html |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 354.7±37.0 °C at 760 mmHg |
| Melting Point | 178-180 °C(lit.) |
| Molecular Formula | C9H5Cl2NO |
| Molecular Weight | 214.048 |
| Flash Point | 168.3±26.5 °C |
| Exact Mass | 212.974823 |
| PSA | 33.12000 |
| LogP | 3.75 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.702 |
| InChIKey | WDFKMLRRRCGAKS-UHFFFAOYSA-N |
| SMILES | Oc1c(Cl)cc(Cl)c2cccnc12 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S37/39-S25-S22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | VC5350000 |
| HS Code | 2933499090 |
Customs
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles7
More Articles| Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides. Org. Lett. 16(3) , 864-7, (2014) A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of cop... | |
| Reverse-phase high-performance liquid chromatographic determination of halogenated 8-hydroxyquinoline compounds in pharmaceuticals and bulk drugs. J. Pharm. Sci. 73(10) , 1430-3, (1984) A reverse-phase high-performance liquid chromatographic (HPLC) method was developed for determining iodochlorhydroxyquin, 5,7-dichloro-8-hydroxyquinoline, and 5,7-diiodo-8-hydroxyquinoline in creams, ... | |
| Effects of chlorhexidine, iodine, and 5,7-dichloro-8-hydroxyquinoline on the bacterial composition of rat plaque in vivo. Caries Res. 18(5) , 440-6, (1984) |
Synonyms
| 5,7-Dichloro-8-quinolinol |
| 5,7-Dichloro-8-hydroxyquinoline |
| EINECS 212-258-3 |
| Chloroxine |
| 5,7-dichloroquinolin-8-ol |
| 8-Quinolinol, 5,7-dichloro- |
| MFCD00006786 |
