CAS 65147-22-0|Z-Phe-Arg-AMC · HCl
| Common Name | Z-Phe-Arg-AMC · HCl | ||
|---|---|---|---|
| CAS Number | 65147-22-0 | Molecular Weight | 612.68 |
| Density | 1.32 g/cm3 | Boiling Point | / |
| Molecular Formula | C33H36N6O6 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride |
|---|---|
| Synonym | More Synonyms |
Z-Phe-Arg-AMC · HCl BiologicalActivity
| Description | N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):246-53. [2]. Porter K,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9(4):581-94. |
Chemical & Physical Properties
| Density | 1.32 g/cm3 |
|---|---|
| Molecular Formula | C33H36N6O6 |
| Molecular Weight | 612.68 |
| Exact Mass | 648.24600 |
| PSA | 188.64000 |
| LogP | 6.17340 |
| Index of Refraction | 1.639 |
| InChIKey | ZZGDDBWFXDMARY-UHFFFAOYSA-N |
| SMILES | Cc1cc(=O)oc2cc(NC(=O)C(CCCN=C(N)N)NC(=O)C(Cc3ccccc3)NC(=O)OCc3ccccc3)ccc12 |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles29
More Articles| Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates. Meth. Enzymol. 80 , 341, (1981) | |
| Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster. PLoS ONE 8(1) , e54187, (2013) Drosophila melanogaster crammer is a novel cathepsin inhibitor involved in long-term memory formation. A molten globule-to-ordered structure transition is required for cathepsin inhibition. This study... | |
| Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC. Immunopharmacology 36(2-3) , 295-303, (1997) Anti-peptide antibodies were produced against the cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei and the effects of these antibodies on enzyme activity against carboxybenzoyl (Z)-Ph... |
Synonyms
| benzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate |
| MFCD00077030 |
