Introduction：Basic information about CAS 186452-09-5|GPI-1046, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GPI-1046 |
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| CAS Number | 186452-09-5 | Molecular Weight | 360.447 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 501.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C20H28N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 257.1±32.9 °C |
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Names
| Name | 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate |
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| Synonym | More Synonyms |
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GPI-1046 BiologicalActivity
| Description | GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| Target | GLT1 |
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| References | [1]. Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35. [2]. Eberling JL, et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol. 2002 Dec;178(2):236-42. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 501.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C20H28N2O4 |
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| Molecular Weight | 360.447 |
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| Flash Point | 257.1±32.9 °C |
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| Exact Mass | 360.204895 |
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| PSA | 90.40000 |
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| LogP | 1.54 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.529 |
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| InChIKey | OQAHHWOPVDDWHD-INIZCTEOSA-N |
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| SMILES | CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCc1cccnc1 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester |
| GPI |
| (S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate |
| 3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)-L-prolinate |
| gpi-1046 |
