Introduction：Basic information about CAS 4812-40-2|Hydroxymetronidazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydroxymetronidazole |
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| CAS Number | 4812-40-2 | Molecular Weight | 187.15300 |
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| Density | 1.61g/cm3 | Boiling Point | 475.2ºC at 760mmHg |
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| Molecular Formula | C6H9N3O4 | Melting Point | 118-121ºC |
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| MSDS | ChineseUSA | Flash Point | 241.2ºC |
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Names
| Name | Hydroxy Metronidazole |
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| Synonym | More Synonyms |
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Hydroxymetronidazole BiologicalActivity
| Description | Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. Rodrigo H M M Granja, et al. Determination and confirmation of metronidazole, dimetridazole, ronidazole and their metabolites in bovine muscle by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):970-6. |
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Chemical & Physical Properties
| Density | 1.61g/cm3 |
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| Boiling Point | 475.2ºC at 760mmHg |
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| Melting Point | 118-121ºC |
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| Molecular Formula | C6H9N3O4 |
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| Molecular Weight | 187.15300 |
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| Flash Point | 241.2ºC |
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| Exact Mass | 187.05900 |
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| PSA | 104.10000 |
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| Index of Refraction | 1.643 |
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| InChIKey | AEHPOYAOLCAMIU-UHFFFAOYSA-N |
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| SMILES | O=[N+]([O-])c1cnc(CO)n1CCO |
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| Storage condition | -20?C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NI5568000
- CHEMICAL NAME :
- Imidazole-1-ethanol, 2-hydroxymethyl-5-nitro-
- CAS REGISTRY NUMBER :
- 4812-40-2
- BEILSTEIN REFERENCE NO. :
- 0883934
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C6-H9-N3-O4
- MOLECULAR WEIGHT :
- 187.18
- WISWESSER LINE NOTATION :
- T5N CNJ A2Q B1Q ENW
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Klebsiella pneumoniae
- DOSE/DURATION :
- 10 umol/L/20H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | 24/25 |
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| RIDADR | NONH for all modes of transport |
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| RTECS | NI5568000 |
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Articles27
More Articles
| Development of a monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for nitroimidazoles in edible animal tissues and feeds. J. Pharm. Biomed. Anal. 120 , 84-91, (2016) The misuse of nitroimidazoles (NDZs) can lead to NDZs residues in edible animal tissues, which would be harmful to consumer health. To quickly monitor NDZs residues in edible animal tissues and feed, ... | |
| Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography-tandem mass spectrometry. Food Chem. 197 , 571-80, (2015) A multiclass method was developed for the simultaneous determination of 120 analytes in fresh eggs. The method covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphona... | |
| Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma. Clin. Chem. 30(5) , 784-7, (1984) Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples de... | |
Synonyms
| 2-[2-(hydroxymethyl)-5-nitroimidazol-1-yl]ethanol |
