Introduction：Basic information about CAS 7728-40-7|Monoethylglycinexylidide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Monoethylglycinexylidide |
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| CAS Number | 7728-40-7 | Molecular Weight | 206.28 |
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| Density | 1.047g/cm3 | Boiling Point | 335.6ºC at 760 mmHg |
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| Molecular Formula | C12H18N2O | Melting Point | 242-245ºC |
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| MSDS | ChineseUSA | Flash Point | 127.8ºC |
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| Symbol |
GHS06 | Signal Word | Danger |
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Names
| Name | monoethylglycinexylidide |
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| Synonym | More Synonyms |
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Monoethylglycinexylidide BiologicalActivity
| Description | Monoethylglycinexylidide is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease |
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| References | [1]. Y S Huang, et al. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol. 1993 Aug;19(1):140-7. |
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Chemical & Physical Properties
| Density | 1.047g/cm3 |
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| Boiling Point | 335.6ºC at 760 mmHg |
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| Melting Point | 242-245ºC |
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| Molecular Formula | C12H18N2O |
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| Molecular Weight | 206.28 |
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| Flash Point | 127.8ºC |
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| Exact Mass | 206.14200 |
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| PSA | 41.13000 |
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| LogP | 2.31530 |
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| Index of Refraction | 1.553 |
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| InChIKey | WRMRXPASUROZGT-UHFFFAOYSA-N |
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| SMILES | CCNCC(=O)Nc1c(C)cccc1C |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AN7740000
- CHEMICAL NAME :
- 2',6'-Acetoxylidide, 2-(ethylamino)-
- CAS REGISTRY NUMBER :
- 7728-40-7
- BEILSTEIN REFERENCE NO. :
- 2417108
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C12-H18-N2-O
- MOLECULAR WEIGHT :
- 206.32
- WISWESSER LINE NOTATION :
- 2M1MVR B1 F1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 234 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 179,580,1971
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H301 |
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| Precautionary Statements | P301 + P310 |
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| RIDADR | UN 2811 6.1 / PGIII |
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| RTECS | AN7740000 |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles31
More Articles
| Transplacental Distribution of Lidocaine and Its Metabolite in Peridural Anesthesia Administered to Patients With Gestational Diabetes Mellitus. Reprod. Sci. 22 , 791-7, (2015) Neonatal effects of drugs administered to mothers before delivery depend on the quantity that crosses the placental barrier, which is determined by the pharmacokinetics of the drug in the mother, fetu... | |
| Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1256-64, (2015) Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under... | |
| MEGX test in hepatology: the long-sought ultimate quantitative liver function test? J. Hepatol. 19(1) , 4-7, (1993)
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Synonyms
| monoethylglycine-2,6-xylidide |
| monoethyl glycine xylidide |
| MEGX |
| N-Ethylglycinexylidide |
| ethylaminoacet-2,6-xylidide |
| L 86 |
| Ethylglycylxylidide |
| desmethyllidocaine |
| 2-ethylamino-2',6'-dimethylacetanilide |
| Norlidocaine |
| 2-Ethylamino-2,6-acetoxylidine |
| 2-Ethylamino-2',6'-acetoxylidide |
| N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide |
