CAS 88899-56-3|Bafilomycin B1
| Common Name | Bafilomycin B1 | ||
|---|---|---|---|
| CAS Number | 88899-56-3 | Molecular Weight | 815.986 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 939.4±65.0 °C at 760 mmHg |
| Molecular Formula | C44H65NO13 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 521.9±34.3 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | Bafilomycin B1 |
|---|---|
| Synonym | More Synonyms |
Bafilomycin B1 BiologicalActivity
| Description | Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Anti-infection >>Bacterial |
| References | [1]. Bowman EJ, et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7972-6. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 939.4±65.0 °C at 760 mmHg |
| Molecular Formula | C44H65NO13 |
| Molecular Weight | 815.986 |
| Flash Point | 521.9±34.3 °C |
| Exact Mass | 815.445618 |
| PSA | 207.38000 |
| LogP | 3.06 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.563 |
| InChIKey | KFUFLYSBMNNJTF-GSHYOGPJSA-N |
| SMILES | COC1=CC(C)=CC(C)C(O)C(C)CC(C)=CC=CC(OC)C(C(C)C(O)C(C)C2(O)CC(OC(=O)C=CC(=O)NC3=C(O)CCC3=O)C(C)C(C(C)C)O2)OC1=O |
| Storage condition | −20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1253,1981
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | R26/27/28 |
| Safety Phrases | 36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | NG8841000 |
Articles28
More Articles| Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc. Natl. Acad. Sci. U. S. A. 85 , 7972, (1988) Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast,... | |
| Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E. Biochim. Biophys. Acta 1126(1) , 41-8, (1992) Two microbial metabolites, bafilomycin B1 and destruxin E, have been found to inhibit significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets at 3 nM and 0.5 mi... | |
| The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells. Cell Biol. Toxicol. 22(3) , 169-81, (2006) Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the prot... |
Synonyms
| (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose |
| BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO-MYCES SPECIES |
| bafilomycin b1from streptomyces sp. |
| α-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-3 -O-[(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-buten-1-yl]-4-methyl-5-C-(1-methylethyl)-, (5R)- |
| ino)carbonyl)-2-methoxy-24-methyl |
| BafilomycinB1fromStreptomycesgriseus |
| MFCD00214150 |
