CAS 477953-07-4|Neostenine

Introduction：Basic information about CAS 477953-07-4|Neostenine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Neostenine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Neostenine
CAS Number	477953-07-4	Molecular Weight	277.40
Density	1.1±0.1 g/cm3	Boiling Point	414.6±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₇NO₂	Melting Point	/
MSDS	/	Flash Point	146.3±19.6 °C

Names

Name	(7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyldodecahydroazepi no[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
Synonym	More Synonyms

Neostenine BiologicalActivity

Description	Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoprotein
References	[1]. Chung HS, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med. 2003 Oct;69(10):914-20. [2]. Leung PH, et al. Intestinal absorption of Stemona alkaloids in a Caco-2 cell model. Planta Med. 2006 Feb;72(3):211-6.

Description

Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoprotein

References

[1]. Chung HS, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med. 2003 Oct;69(10):914-20.

[2]. Leung PH, et al. Intestinal absorption of Stemona alkaloids in a Caco-2 cell model. Planta Med. 2006 Feb;72(3):211-6.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	414.6±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₇NO₂
Molecular Weight	277.40
Flash Point	146.3±19.6 °C
Exact Mass	277.204193
PSA	29.54000
LogP	2.91
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.544
InChIKey	ROIHYOJMCBKEER-UHFFFAOYSA-N
SMILES	CCC1C2CCCCN3CCC(C4C(C)C(=O)OC14)C23

Safety Information

Hazard Codes	Xi

Synonyms

Azepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one, 8-ethyldodecahydro-11-methyl-, (7aR,8R,8aR,11S,11aR,11bS,11cR)-

(7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyldodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one

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