CAS 501-96-2|Rhododendrol
Introduction：Basic information about CAS 501-96-2|Rhododendrol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rhododendrol | ||
|---|---|---|---|
| CAS Number | 501-96-2 | Molecular Weight | 166.22 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 315.4±17.0 °C at 760 mmHg |
| Molecular Formula | C10H14O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 153.4±15.5 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4-[(3R)-3-Hydroxybutyl]phenol |
|---|---|
| Synonym | More Synonyms |
Rhododendrol BiologicalActivity
| Description | Rhododendrol can induce leukoderma. Rhododendrol induces generation of hydroxyl radicals and melanocyte cytotoxicity by increasing glutathione levels. Rhododendrol is a phenolic compound that can be isolated from plants such as Acer nikoense and Betula platyphylla[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| References | [1]. Gabe Y, et al. Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma. J Dermatol Sci. 2018 Sep;91(3):311-316. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 315.4±17.0 °C at 760 mmHg |
| Molecular Formula | C10H14O2 |
| Molecular Weight | 166.22 |
| Flash Point | 153.4±15.5 °C |
| Exact Mass | 166.099380 |
| PSA | 40.46000 |
| LogP | 1.49 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.552 |
| InChIKey | SFUCGABQOMYVJW-MRVPVSSYSA-N |
| SMILES | CC(O)CCc1ccc(O)cc1 |
| Storage condition | ?20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
Articles2
More Articles| T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma. Dermatology 232 , 44-9, (2016) Rhododendrol, a phenolic compound contained in lightening/whitening cosmetics, can bind and inhibit tyrosinase and was reported to induce leukoderma in Japan. Only 2% of the cosmetics users are affect... | |
| Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. Pigment Cell Melanoma Res. 27(5) , 754-63, (2014) Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of repeated chemical cont... |
Synonyms
| 4-[(3R)-3-Hydroxybutyl]phenol |
| Benzenepropanol, 4-hydroxy-α-methyl- |
| 4-(3-Hydroxybutyl)phenol |
| 4-(p-Hydroxyphenyl)-2-butanol |
| Benzenepropanol, 4-hydroxy-α-methyl-, (R)- |
| Benzenepropanol, 4-hydroxy-α-methyl-, (αR)- |
| 2-Butanol, 4-(p-hydroxyphenyl)- |
| UNII:12QWN45UL0 |
| Rhododendrol |
| (-)-Rhododendrol |
