Introduction：Basic information about CAS 415713-60-9|RI-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | RI-1 |
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| CAS Number | 415713-60-9 | Molecular Weight | 361.608 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 483.0±45.0 °C at 760 mmHg |
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| Molecular Formula | C14H11Cl3N2O3 | Melting Point | / |
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| MSDS | USA | Flash Point | 245.9±28.7 °C |
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Names
| Name | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione |
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| Synonym | More Synonyms |
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RI-1 BiologicalActivity
| Description | RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.IC50 Value: 5-30 μMTarget: RAD51in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. in vivo: |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>RAD51Research Areas >>Cancer |
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| References | [1]. dke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 May 9. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 483.0±45.0 °C at 760 mmHg |
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| Molecular Formula | C14H11Cl3N2O3 |
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| Molecular Weight | 361.608 |
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| Flash Point | 245.9±28.7 °C |
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| Exact Mass | 359.983521 |
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| PSA | 49.85000 |
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| LogP | 3.04 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.669 |
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| InChIKey | MWSUIZKGNWELRF-UHFFFAOYSA-N |
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| SMILES | O=C1C(Cl)=C(N2CCOCC2)C(=O)N1c1ccc(Cl)c(Cl)c1 |
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| Storage condition | -20°C |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| 1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)- |
| 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione |
| S8077,RAD51 inhibitor 1 |
| 3-Chloro-1-(3,4-dichloro-phenyl)-4-morpholin-4-yl-pyrrole-2,5-dione |
| 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione |
| RI-1 |
