Introduction：Basic information about CAS 186020-66-6|Hydroxy-PEG3-(CH2)2-Boc, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydroxy-PEG3-(CH2)2-Boc |
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| CAS Number | 186020-66-6 | Molecular Weight | 278.34200 |
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| Density | 1.057g/cm3 | Boiling Point | 365.8ºC at 760 mmHg |
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| Molecular Formula | C13H26O6 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 125.2ºC |
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Names
| Name | tert-butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate |
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| Synonym | More Synonyms |
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Hydroxy-PEG3-(CH2)2-Boc BiologicalActivity
| Description | Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
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| References | [1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2. |
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Chemical & Physical Properties
| Density | 1.057g/cm3 |
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| Boiling Point | 365.8ºC at 760 mmHg |
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| Molecular Formula | C13H26O6 |
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| Molecular Weight | 278.34200 |
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| Flash Point | 125.2ºC |
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| Exact Mass | 278.17300 |
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| PSA | 74.22000 |
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| LogP | 0.76030 |
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| Vapour Pressure | 7.78E-07mmHg at 25°C |
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| Index of Refraction | 1.45 |
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| InChIKey | KSXVEOLRERRELV-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)CCOCCOCCOCCO |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2918990090 |
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Customs
| HS Code | 2918990090 |
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| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles1
More Articles
Angew. Chem. Int. Ed. Engl. 113 , 379, (2001)
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Synonyms
| Hydroxy-PEG3-t-butyl ester |
| 12-hydroxy-4,7,10-trioxadodecanoic acid tert-butyl ester |
| tert-Butyl triethylene glycol-O-propionate |
| tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate |
