Introduction：Basic information about CAS 33676-00-5|Hypophyllanthin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hypophyllanthin |
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| CAS Number | 33676-00-5 | Molecular Weight | 430.491 |
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| Density | 1.158 | Boiling Point | 511.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C24H30O7 | Melting Point | 129-130℃ |
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| MSDS | / | Flash Point | 200.8±30.0 °C |
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Names
| Name | (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole |
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| Synonym | More Synonyms |
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Hypophyllanthin BiologicalActivity
| Description | Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoprotein |
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| Target | P-gp[2] |
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| In Vitro | Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1]. |
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| References | [1]. Harikrishnan H, et al. Anti-Inflammatory Effects of Hypophyllanthin and Niranthin Through Downregulation of NF-κB/MAPKs/PI3K-Akt Signaling Pathways. Inflammation. 2018 Jun;41(3):984-995. [2]. Sukhaphirom N, et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. J Pharm Pharmacol. 2013 Feb;65(2):292-9. |
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Chemical & Physical Properties
| Density | 1.158 |
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| Boiling Point | 511.1±50.0 °C at 760 mmHg |
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| Melting Point | 129-130℃ |
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| Molecular Formula | C24H30O7 |
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| Molecular Weight | 430.491 |
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| Flash Point | 200.8±30.0 °C |
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| Exact Mass | 430.199158 |
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| PSA | 64.61000 |
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| LogP | 3.77 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.536 |
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| InChIKey | LBJCUHLNHSKZBW-XGHQBKJUSA-N |
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| SMILES | COCC1Cc2cc(OC)c3c(c2C(c2ccc(OC)c(OC)c2)C1COC)OCO3 |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R22 |
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Synonyms
| (7R,8R,9S)-9-(3,4-Dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxole |
| UNII:22ZZ21E33P |
| Naphtho[1,2-d]-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7R,8R,9S)- |
| Hypophyllanthin |
| Hypophyllantin |
