Introduction：Basic information about CAS 64657-21-2|Isoforskolin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Isoforskolin |
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| CAS Number | 64657-21-2 | Molecular Weight | 410.501 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 524.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H34O7 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 173.6±23.6 °C |
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Names
| Name | Coleonol B |
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| Synonym | More Synonyms |
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Isoforskolin BiologicalActivity
| Description | Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/Immunology |
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| In Vitro | Isoforskolin downregulates the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA)[1]. |
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| References | [1]. Zhao H, et al. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A.Exp Ther Med. 2017 Dec;14(6):5974-5980. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 524.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H34O7 |
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| Molecular Weight | 410.501 |
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| Flash Point | 173.6±23.6 °C |
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| Exact Mass | 410.230438 |
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| PSA | 113.29000 |
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| LogP | 3.40 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.552 |
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| InChIKey | CLOQVZCSBYBUPB-VDCUXWMXSA-N |
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| SMILES | C=CC1(C)CC(=O)C2(O)C(C)(O1)C(O)C(OC(C)=O)C1C(C)(C)CCC(O)C12C |
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| Storage condition | −20°C |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 21 |
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| Safety Phrases | 36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Synonyms
| Isoforskolin |
| (3R,4aR,5S,6S,10S,10aR,10bS)-5,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-6-yl acetate |
| 1H-Naphtho[2,1-b]pyran-1-one, 6-(acetyloxy)-3-ethenyldodecahydro-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,10S,10aR,10bS)- |
| 6-Acetyl-7-deacetylforskolin |
