CAS 82248-59-7|Atomoxetine Hydrochloride
| Common Name | Atomoxetine Hydrochloride | ||
|---|---|---|---|
| CAS Number | 82248-59-7 | Molecular Weight | 291.816 |
| Density | / | Boiling Point | 389ºC at 760 mmHg |
| Molecular Formula | C17H22ClNO | Melting Point | 167-169ºC |
| MSDS | USA | Flash Point | 164.1ºC |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | atomoxetine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Atomoxetine Hydrochloride BiologicalActivity
| Description | Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). IC50 value: 5 nM (Ki for human NET)Target: NETAtomoxetine displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Atomoxetine is antidepressant and a commonly used non-stimulant treatment for Attention deficit hyperactivity disorder (ADHD). |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| References | [1]. McAfee AT, Landon J, Jones M, et al. A cohort study of the risk of seizures in a pediatric population treated with atomoxetine or stimulant medications. Pharmacoepidemiol Drug Saf. 2012 Dec 26. [2]. Turner M, Wilding E, Cassidy E, Dommett EJ. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2012 Dec 22;243C:28-37. [3]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 N [4]. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther. 1997 Dec;283(3):1305-22. [5]. Atomoxetine |
Chemical & Physical Properties
| Boiling Point | 389ºC at 760 mmHg |
|---|---|
| Melting Point | 167-169ºC |
| Molecular Formula | C17H22ClNO |
| Molecular Weight | 291.816 |
| Flash Point | 164.1ºC |
| Exact Mass | 291.138977 |
| PSA | 21.26000 |
| LogP | 4.91750 |
| InChIKey | LUCXVPAZUDVVBT-UNTBIKODSA-N |
| SMILES | CNCCC(Oc1ccccc1C)c1ccccc1.Cl |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | S22-S24/25 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| HS Code | 2922299090 |
Customs
| HS Code | 2922299090 |
|---|---|
| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles45
More Articles| Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats. J. Neurosci. 35(1) , 161-9, (2015) Positive social interactions during the juvenile and adolescent phases of life, in the form of social play behavior, are important for social and cognitive development. However, the neural mechanisms ... | |
| Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice. J. Pharmacol. Exp. Ther. 351(3) , 663-73, (2014) Skeletal muscle atrophy remains a clinical problem in numerous pathologic conditions. β2-Adrenergic receptor agonists, such as formoterol, can induce mitochondrial biogenesis (MB) to prevent such atro... | |
| Current pharmacotherapy of attention deficit hyperactivity disorder. Drugs Today (Barc) 49(10) , 647-65, (2013) Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder in children and adults characterized by a persistent pattern of impulsiveness, inattention and hyperactivity... |
Synonyms
| Atomoxetine HCL |
| benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride |
| (gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine Hydrochloride |
| (3R)-N-méthyl-3-(2-méthylphénoxy)-3-phénylpropan-1-amine chlorhydrate |
| MFCD06410992 |
| (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride (1:1) |
| Atomoxetine hydrochloride |
| EINECS 200-659-6 |
| (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride |
| (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-aminhydrochlorid |
| (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1) |
| Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride (1:1) |
| Atomoxetine (hydrochloride) |
