CAS 97748-75-9|2'-Azido-2'-deoxy-5-methyluridine

Introduction:Basic information about CAS 97748-75-9|2'-Azido-2'-deoxy-5-methyluridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name2'-Azido-2'-deoxy-5-methyluridine
CAS Number97748-75-9Molecular Weight283.24
Density/Boiling Point/
Molecular FormulaC10H13N5O5Melting Point/
MSDS/Flash Point/

Names

NameUridine, 2'-azido-2'-deoxy-5-methyl
SynonymMore Synonyms

2'-Azido-2'-deoxy-5-methyluridine BiologicalActivity

Description2′-Azido-2′-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

Molecular FormulaC10H13N5O5
Molecular Weight283.24
Exact Mass283.09200
PSA154.30000
InChIKeyJEIPQKWFUIEONT-UHFFFAOYSA-N
SMILESCc1cn(C2OC(CO)C(O)C2N=[N+]=[N-])c(=O)[nH]c1=O

Synonyms

2'-AZIDO-2'-DEOXY-5-METHYLURIDINE
1-[(2R,3R,4S,5R)-3-azido-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
2'-Azido-2'-deoxy-5-methyl uridine
URIDINE, 2'-AZIDO-2'-DEOXY-5-METHYL-
2'-Deoxy-2'-azidoribothymidine
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