Introduction：Basic information about CAS 22688-78-4|Kaempferol-3-beta-O-glucuronide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kaempferol-3-beta-O-glucuronide |
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| CAS Number | 22688-78-4 | Molecular Weight | 462.360 |
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| Density | 1.9±0.1 g/cm3 | Boiling Point | 876.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C21H18O12 | Melting Point | 189-191 °C |
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| MSDS | / | Flash Point | 309.8±27.8 °C |
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Names
| Name | (2S,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
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| Synonym | More Synonyms |
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Kaempferol-3-beta-O-glucuronide BiologicalActivity
| Description | Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10[1][2]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/Immunology |
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| References | [1]. Khajuria V, et al. Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model. Int Immunopharmacol. 2018;57:62-71. [2]. DuPont MS, et al. Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. Eur J Clin Nutr. 2004;58(6):947-954. |
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Chemical & Physical Properties
| Density | 1.9±0.1 g/cm3 |
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| Boiling Point | 876.8±65.0 °C at 760 mmHg |
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| Melting Point | 189-191 °C |
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| Molecular Formula | C21H18O12 |
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| Molecular Weight | 462.360 |
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| Flash Point | 309.8±27.8 °C |
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| Exact Mass | 462.079834 |
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| PSA | 207.35000 |
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| LogP | 2.30 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.789 |
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| InChIKey | FNTJVYCFNVUBOL-ZUGPOPFOSA-N |
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| SMILES | O=C(O)C1OC(Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)C(O)C(O)C1O |
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| Storage condition | ?20°C |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26 |
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Synonyms
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl D-glucopyranosiduronic acid |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl β-D-glucopyranosiduronic acid |
| Kaempferol 3-O-|A-D-glucuronide |
| 4H-1-Benzopyran-4-one, 3-(D-glucopyranuronosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| 4H-1-Benzopyran-4-one, 3-(β-D-glucopyranuronosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| Kaempferol-3-Glucuronide |
| Kaempferol 3-glucuronide |
