CAS 456-04-2|4-Fluorophenacyl chloride

Introduction：Basic information about CAS 456-04-2|4-Fluorophenacyl chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles4
7. Synonyms

Common Name	4-Fluorophenacyl chloride
CAS Number	456-04-2	Molecular Weight	172.584
Density	1.3±0.1 g/cm3	Boiling Point	247.0±15.0 °C at 760 mmHg
Molecular Formula	C₈H₆ClFO	Melting Point	47-50 °C(lit.)
MSDS	USA	Flash Point	103.2±20.4 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	2-Chloro-4'-fluoroacetophenone
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	247.0±15.0 °C at 760 mmHg
Melting Point	47-50 °C(lit.)
Molecular Formula	C₈H₆ClFO
Molecular Weight	172.584
Flash Point	103.2±20.4 °C
Exact Mass	172.009125
PSA	17.07000
LogP	1.90
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.514
InChIKey	UJZWJOQRSMOFMA-UHFFFAOYSA-N
SMILES	O=C(CCl)c1ccc(F)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM6550000

CHEMICAL NAME :: Acetophenone, 2-chloro-4'-fluoro-

CAS REGISTRY NUMBER :: 456-04-2

BEILSTEIN REFERENCE NO. :: 0637860

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H6-Cl-F-O

MOLECULAR WEIGHT :: 172.59

WISWESSER LINE NOTATION :: G1VR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05172

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	T:Toxic;Xi:Irritant;
Risk Phrases	R23/25;R34;R36/37/38
Safety Phrases	S26-S28-S45-S36/37/39
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	AM6550000
Packaging Group	II
Hazard Class	8
HS Code	2914700090

Customs

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles4

Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones.

Chem. Res. Toxicol. 20(1) , 149-54, (2007)

S-(Phenacyl)glutathione reductase (SPG-R) plays a significant role in the biotransformation of reactive alpha-haloketones to nontoxic acetophenones. Comparison of the apparent subunit size, amino acid...

Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.

Bioorg. Med. Chem. 17(4) , 1716-23, (2009)

Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous re...

Allergic contact dermatitis from 3-(alpha-methoxy) methylenebenzofuran-2(3H)-one (MBF) and alpha-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.

Contact Dermatitis 34(6) , 434-5, (1996)

Synonyms

α-Chloro-p-fluoroacetophenone

G1VR DF

α-Chloro-para-fluoroacetophenone

2-chloro-4'-fluoro-acetophenone

α-Chloro-4'-fluoroacetophenone

A-CHLORO-4-FLUOROACETOPHENONE

p-Fluorophenacyl chloride

Fluorophenacylchloride

MFCD00011652

2-Chloro-4′-fluoroacetophenone

Ethanone, 2-chloro-1-(4-fluorophenyl)-

4-Fluorchloracetophenone

2-Chloro-1-(4-fluorophenyl)ethan-1-one

Ethanone, 2-chloro-1-(4-fluorophenyl)- (9CI)

2-Chloro-4'-fluoroacetophenone

Acetophenone, α-chloro-4'-fluoro-

EINECS 207-256-4

2-Chloro-4‘-fluoroacetophenone

Acetophenone, 2-chloro-4'-fluoro-

2-Chloro-4'-fluoroac

4-Fluorophenacyl chloride

2-Chloro-1-(4-fluorophenyl)ethanone

ω-Chloro-4'-fluoroacetophenone

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