CAS 641-12-3|Sennidin A

Introduction：Basic information about CAS 641-12-3|Sennidin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sennidin A BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Sennidin A
CAS Number	641-12-3	Molecular Weight	538.458
Density	1.7±0.1 g/cm3	Boiling Point	801.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₀H₁₈O₁₀	Melting Point	/
MSDS	/	Flash Point	452.6±30.8 °C

Names

Name	sennidine a
Synonym	More Synonyms

Sennidin A BiologicalActivity

Description	Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation[1][2].
Related Catalog	Signaling Pathways >>Anti-infection >>HCVResearch Areas >>InfectionSignaling Pathways >>PI3K/Akt/mTOR >>Akt
References	[1]. Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16(8):18439-53. [2]. Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.

Description

Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation[1][2].

Related Catalog

Signaling Pathways >>Anti-infection >>HCVResearch Areas >>InfectionSignaling Pathways >>PI3K/Akt/mTOR >>Akt

References

[1]. Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16(8):18439-53.

[2]. Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	801.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₀H₁₈O₁₀
Molecular Weight	538.458
Flash Point	452.6±30.8 °C
Exact Mass	538.090027
PSA	189.66000
LogP	8.24
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.806
InChIKey	JPMRHWLJLNKRTJ-UHFFFAOYSA-N
SMILES	O=C(O)c1cc(O)c2c(c1)C(C1c3cccc(O)c3C(=O)c3c(O)cc(C(=O)O)cc31)c1cccc(O)c1C2=O
Storage condition	2-8℃

Safety Information

Risk Phrases	22
Safety Phrases	22-45

Synonyms

SENECIONINE(SH)

1',1,8',8-Tetrahydroxy-10,10'-dihydroanthrone-3,3'-dicarboxylic acid

EINECS 211-371-5

dihydroxydianthrone

(+)-4,5,4',5'-tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarboxylic acid

4,4',5,5'-Tetrahydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid

(R*,R*)-(+)-9,9',10,10'-Tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid

[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo-

Sennidin A

(+)-4,5,4',5'-Tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarbonsaeure

(+)-4.5.4'.5'-Tetrahydroxy-10.10'-dioxo-9.10.9'.10'-tetrahydro-[9.9']bianthryl-dicarbonsaeure-(2.2')

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