CAS 18683-91-5|ambroxol

Introduction：Basic information about CAS 18683-91-5|ambroxol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ambroxol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	ambroxol
CAS Number	18683-91-5	Molecular Weight	378.103
Density	1.7±0.1 g/cm3	Boiling Point	468.6±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₈Br₂N₂O	Melting Point	233-234ºC
MSDS	/	Flash Point	237.2±28.7 °C

Names

Name	Ambroxol
Synonym	More Synonyms

ambroxol BiologicalActivity

Description	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Others

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	468.6±45.0 °C at 760 mmHg
Melting Point	233-234ºC
Molecular Formula	C₁₃H₁₈Br₂N₂O
Molecular Weight	378.103
Flash Point	237.2±28.7 °C
Exact Mass	375.978577
PSA	58.28000
LogP	2.91
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.654

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GV8423000

CHEMICAL NAME :: Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)- (E)-

CAS REGISTRY NUMBER :: 18683-91-5

LAST UPDATED :: 199209

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C13-H18-Br2-N2-O

MOLECULAR WEIGHT :: 378.15

WISWESSER LINE NOTATION :: L6TJ AQ DM1R BZ CE EE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 268 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 140 gm/kg/28D-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,281,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 14 gm/kg/28D-C

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - normocytic anemia Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,281,1981

Safety Information

Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S36
WGK Germany	3
RTECS	GV8423000
HS Code	2922199090

Customs

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-

Mucosan

Solvolan

Pect

MFCD00242702

4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol

2-amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzylamine

Mucofar

Motosol

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol

Sufactal

N-(trans-4-hydroxy-cyclohexyl)-2-amino-3,5-dibromo-benzylamine

Fluibron

NA-872

Lindoxyl

4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol

EINECS 242-500-3

Recommended......