CAS 64211-46-7|Oxiconazole nitrate
Introduction：Basic information about CAS 64211-46-7|Oxiconazole nitrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxiconazole nitrate | ||
|---|---|---|---|
| CAS Number | 64211-46-7 | Molecular Weight | 492.14 |
| Density | / | Boiling Point | 576.8ºC |
| Molecular Formula | C18H14Cl4N4O4 | Melting Point | 137-1380C |
| MSDS | ChineseUSA | Flash Point | 302.6ºC |
Names
| Name | oxiconazole nitrate |
|---|---|
| Synonym | More Synonyms |
Oxiconazole nitrate BiologicalActivity
| Description | Oxiconazole nitrate is a broad spectrum antifungal which can inhibit the growth of T. tonsurans and T. rubrum with MIC90s of 0.25 and 0.5 μg/mL, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Infection |
| Target | MIC90: 0.25 μg/mL (T. tonsurans), 0.5 μg/mL (T. rubrum)[1] |
| In Vitro | Oxiconazole nitrate is the more active compound in tests with T. tonsurans and T. rubrum. Twelve isolates are inhibited by 0.063 μg/mL of oxiconazole; corresponding econazole MICs range from 0.063 (three isolates) to 8 (two isolates) μg/mL. Three isolates have oxiconazole MICs of 16 or 32 μg/mL[1]. |
| In Vivo | The baseline distortion product otoacoustic emission (DPOAE) results of the right ears of all animals tested are normal. Animals in groups I, II, IV and V show no statistically significant change in the DPOAE amplitudes. The rats in the gentamicingroup show a significant decrease[2]. |
| Cell Assay | A total of 121 isolates of pathogenic fungi are tested. The three drugs (including Oxiconazole nitrate) are serially diluted in sterile saline. For each test plate, 2 mL of a solution of drug in sterile saline is added to an 18 mL blank of molten agar medium at 50°C and mixed well; the resulting mixtures are then poured into the plates and allowed to solidify. The resulting drug dilution sequences range from 128 to 0.063 μg/mL. Control plates are prepared in a similar manner using 2 mL blanks of sterile saline. The plates are then inoculated using a replicator. Incubation is at 30°C for a minimum of 96 hr. The Minimal Inhibitory Concentration (MIC) is defined as the lowest concentration of drug producing complete inhibition of growth[1]. |
| Animal Admin | Fifty adult rats are divided into 5 groups consisting of 10 animals each. Over 14 days, the rats in group I receive 0.1 mL of Oxiconazole nitrate-containing solution drops, group II receives 4% boric acid solution in alcohol drops, and groups III and IV receive gentamicin (40 mg/mL) and saline solutions, respectively. Group V receives no medication. Each solution used is given twice a day[2]. |
| References | [1]. Shadomy S, et al. Further in vitro studies with oxiconazole nitrate. Diagn Microbiol Infect Dis. 1988 Apr;9(4):231-7. [2]. Özdemir S, et al. Effects of topical oxiconazole and boric acid in alcohol solutions to rat inner ears. Otolaryngol Head Neck Surg. 2013 Jun;148(6):1023-7. |
Chemical & Physical Properties
| Boiling Point | 576.8ºC |
|---|---|
| Melting Point | 137-1380C |
| Molecular Formula | C18H14Cl4N4O4 |
| Molecular Weight | 492.14 |
| Flash Point | 302.6ºC |
| PSA | 105.46000 |
| LogP | 6.15550 |
| InChIKey | WVNOAGNOIPTWPT-UHFFFAOYSA-N |
| SMILES | Clc1ccc(CON=C(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1.O=[N+]([O-])O |
| Storage condition | Refrigerator |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2458 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 37,1355,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 630 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >7500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,227,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2630 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 595 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,365,1986
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >15 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,227,1990
Safety Information
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | 37/39-26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | CQ7700000 |
| HS Code | 29335995 |
Customs
| HS Code | 29335995 |
|---|
Synonyms
| Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-(2,4-dichlorophenyl)oxime, (1Z)-, nitrate (1:1) |
| MFCD00865580 |
| Oxiconazole nitrate |
| (1Z)-N-(2,4-Dichlorophenoxy)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine nitrate (1:1) |
| EINECS 264-730-3 |
| (z)-1-(2-(2,4-dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1h-IMIDAZOLE mononitrate |
