CAS 623-05-2|4-Hydroxybenzyl alcohol
| Common Name | 4-Hydroxybenzyl alcohol | ||
|---|---|---|---|
| CAS Number | 623-05-2 | Molecular Weight | 124.137 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 252.0±0.0 °C at 760 mmHg |
| Molecular Formula | C7H8O2 | Melting Point | 114-122 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 145.8±15.0 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | p-hydroxybenzyl alcohol |
|---|---|
| Synonym | More Synonyms |
4-Hydroxybenzyl alcohol BiologicalActivity
| Description | 4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological DiseaseNatural Products >>Phenols |
| In Vitro | 4-Hydroxybenzyl alcohol inhibits proliferation of eEND2 cells and suppresses the migration of eEND2 cells, accompanied by inhibition of actin filament reorganization[2]. 4-Hydroxybenzyl alcohol induces apoptotic death of tumor cells[3]. |
| In Vivo | 4-Hydroxybenzyl alcohol possesses antiangiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production[1]. 4-Hydroxybenzyl alcohol (200 mg/kg) efficiently inhibits growth and angiogenesis of developing tumors[3]. 4-Hydroxybenzyl alcohol ameliorates ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect may be partly related to attenuate apoptosis pathway[4]. |
| References | [1]. Lim EJ, et al. Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol. J Pharm Pharmacol. 2007 Sep;59(9):1235-40. [2]. Laschke MW, et al. In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol. Br J Pharmacol. 2011 Jun;163(4):835-44. [3]. Laschke MW, et al. 4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth. Life Sci. 2013 Jul 19;93(1):44-50. [4]. Yu SS, et al. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Res. 2010 Jan 13;1308:167-75. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 252.0±0.0 °C at 760 mmHg |
| Melting Point | 114-122 °C(lit.) |
| Molecular Formula | C7H8O2 |
| Molecular Weight | 124.137 |
| Flash Point | 145.8±15.0 °C |
| Exact Mass | 124.052429 |
| PSA | 40.46000 |
| LogP | 0.30 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.596 |
| InChIKey | BVJSUAQZOZWCKN-UHFFFAOYSA-N |
| SMILES | OCc1ccc(O)cc1 |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DA4796800 |
| HS Code | 29072900 |
Customs
| HS Code | 2907299090 |
|---|---|
| Summary | 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0% |
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Synonyms
| 4-(Hydroxymethyl)benzolol |
| (4-Hydroxyphenyl)methanol |
| Gastrodigenin |
| p-Methylolphenol |
| 4-hydroxymethyl-phenol |
| PARA-ALCOHOLPHENOL |
| 4-Hydroxybenzyl alcohol |
| 4-hydroxybenzyl-alcohol |
| Benzyl alcohol, p-hydroxy- (8CI) |
| p-(Hydroxymethyl)phenol |
| p-Hydroxybenzyl |
| 4-(Hydroxymethyl)phenol |
| RARECHEM AL BD 0098 |
| EINECS 210-768-0 |
| Benzenemethanol, 4-hydroxy- |
| Benzyl alcohol, p-hydroxy- |
| 4-METHYLOLPHENOL |
| benzyl alcohol, 4-hydroxy- |
| P-HYDROXYBENZYL ALCOHOL |
| MFCD00004658 |
| 4-HYDROXY-BENZYL-ALCOHOL |
| α-Hydroxy-p-cresol |
| FEMA 3987 |
| Bisoprolol Impurity 19 |
