CAS 6485-40-1|L(-)-Carvone
Introduction：Basic information about CAS 6485-40-1|L(-)-Carvone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L(-)-Carvone | ||
|---|---|---|---|
| CAS Number | 6485-40-1 | Molecular Weight | 150.218 |
| Density | 0.958 | Boiling Point | 227-230 ºC |
| Molecular Formula | C10H14O | Melting Point | 25.2ºC |
| MSDS | ChineseUSA | Flash Point | 88 ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (-)-carvone |
|---|---|
| Synonym | More Synonyms |
L(-)-Carvone BiologicalActivity
| Description | (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
| Target | eel AChE:2.19 mM (Ki) |
| In Vitro | (-)-Carvone (3.04 mM; 30 min) inactivates eel AChE with Ki value of 2.19 mM[1]. |
| In Vivo | (-)-Carvone (5% in absolute ethanol v/v, 20 μL; application to the thoraces ventral surfaces) inhibits AChE such as horse serum cholinesterase, house fly head cholinesterases, and head and thorax cholinesterases from the Madagascar roach in vitro[1]. (-)-Carvone (0.05%-0.1% w/v; p.o.; 7 d) inhibits E. insulana larvae growth, decreases weight of larvae[2]. Animal Model: Female roaches (Gromphadorhina portentosa) (6.4 g-6.8 g)[1] Dosage: 5% in absolute ethanol v/v, 20 μL Administration: Application to the ventral surfaces of their thoraces; decapitated and crude at various time intervals (0, 2, 4, 5, 20, 24, and 26 hr) Result: Inhibited the activity of AChE in the extracts of both the head and thorax. |
| References | [1]. Grundy D L, et al. Inhibition of acetylcholinesterases by pulegone-1, 2-epoxide[J]. Pesticide biochemistry and physiology, 1985, 23(3): 383-388. [2]. Meisner J, et al. The response of Earias insulana Boisd. larvae to phagodeterrent (–)‐carvone incorporated in an artificial diet 1[J]. Zeitschrift für Angewandte Entomologie, 1980, 90(1‐5): 80-82. |
Chemical & Physical Properties
| Density | 0.958 |
|---|---|
| Boiling Point | 227-230 ºC |
| Melting Point | 25.2ºC |
| Molecular Formula | C10H14O |
| Molecular Weight | 150.218 |
| Flash Point | 88 ºC |
| Exact Mass | 150.104462 |
| PSA | 17.07000 |
| LogP | 2.27 |
| Vapour density | 5.2 (vs air) |
| Vapour Pressure | 0.1±0.5 mmHg at 25°C |
| Index of Refraction | 1.481 |
| InChIKey | ULDHMXUKGWMISQ-SECBINFHSA-N |
| SMILES | C=C(C)C1CC=C(C)C(=O)C1 |
| Water Solubility | PRACTICALLY INSOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1640 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1057,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02834
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 766 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1057,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8585 No. of Facilities: 459 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 19245 (estimated) No. of Female Employees: 10383 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | OS8650000 |
| HS Code | 29142900 |
Customs
| HS Code | 2914299000 |
|---|---|
| Summary | 2914299000. other cyclanic, cyclenic or cyclotherpenic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
Articles36
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Synonyms
| Carvone |
| UNII:75GK9XIA8I |
| 2-Methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-on |
| 5-Isopropenyl-2-methyl-2-cyclohexen-1-one |
| (5R)-2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one |
| 2-Cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)- |
| Levo-carvone |
| EINECS 229-352-5 |
| MFCD00001578 |
| 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one |
| L(-)-Carvone |
