CAS 6591-63-5|Quinidine sulfate dihydrate

Introduction：Basic information about CAS 6591-63-5|Quinidine sulfate dihydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Quinidine sulfate dihydrate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles8
7. Synonyms

Common Name	Quinidine sulfate dihydrate
CAS Number	6591-63-5	Molecular Weight	782.943
Density	/	Boiling Point	992.5ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O_2.1/₂H₂O₄S_.H₂O	Melting Point	212-214 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	554ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	Quinidine sulfate salt dihydrate
Synonym	More Synonyms

Quinidine sulfate dihydrate BiologicalActivity

Description	Quinidine sulfate dihydrate is a potent and selective inhibitor of cytochrome P450db and inhibits amphetamine metabolism in vivo[1]. Quinidine sulfate dihydrate enhances the cytotoxicity of vincristine (VCR) in tumor cells and especially in VCR-resistant sublines of P388 leukemia (P388/VCR) and human myelogenous leukemia[2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450
Target	IC50: cytochrome P450db; amphetamine metabolism[1]
References	[1]. David E. Moody, et al. Quinidine Inhibits In Vivo Metabolism of Amphetamine in Rats: Impact upon Correlation between GCIMS and Immunoassay Findings in Rat Urine. ournal of Analytical Toxicology, Vol. 14, September/October 1990 [2]. Tsuruo T, et al. Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.Cancer Res. 1984 Oct;44(10):4303-7.

Chemical & Physical Properties

Boiling Point	992.5ºC at 760 mmHg
Melting Point	212-214 °C (dec.)(lit.)
Molecular Formula	C₂₀H₂₄N₂O_2.1/₂H₂O₄S_.H₂O
Molecular Weight	782.943
Flash Point	554ºC
Exact Mass	782.356079
PSA	192.62000
LogP	6.52160
Index of Refraction	275 ° (C=2, 0.1mol/L HCl)
InChIKey	ZHNFLHYOFXQIOW-AHSOWCEXSA-N
SMILES	C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.O.O.O=S(=O)(O)O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA5605000

CHEMICAL NAME :: Quinidine, hemisulfate, hydrate

CAS REGISTRY NUMBER :: 6591-63-5

LAST UPDATED :: 198708

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H24-N2-O2.1/2H2-O4-S.H2-O

MOLECULAR WEIGHT :: 391.52

WISWESSER LINE NOTATION :: T66 A B CNTJ A1U1 DYQ- ET66 BNJ HO1 2 &..H2.S-O4 &QH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	13-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	VA5605000

Articles8

Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.

Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014)

Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemoth...

Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain.

AAPS J. 16(5) , 1029-37, (2014)

Nearly all bodily processes exhibit circadian rhythmicity. As a consequence, the pharmacokinetic and pharmacodynamic properties of a drug may also vary with time of day. The objective of this study wa...

Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys.

Biopharm. Drug Dispos. 36(1) , 15-33, (2015)

Aliskiren is a substrate for P-glycoprotein (P-gp) and is metabolized via cytochrome P450 3A4 (CYP3A4). The aim of the present study was to assess whether P-gp influenced the pharmacokinetics of alisk...

Synonyms

Quinidine Sulfate Dihydrate

Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate, hydrate (2:1:2) (salt)

EINECS 200-046-3

(9S)-6'-Methoxycinchonan-9-ol sulfate hydrate (2:1:2)

MFCD00149346

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