Introduction：Basic information about CAS 82009-34-5|Cilastatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cilastatin |
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| CAS Number | 82009-34-5 | Molecular Weight | 358.45300 |
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| Density | 1.275 g/cm3 | Boiling Point | 655.5ºC at 760 mmHg |
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| Molecular Formula | C16H26N2O5S | Melting Point | 156-158ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | cilastatin |
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| Synonym | More Synonyms |
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Cilastatin BiologicalActivity
| Description | Cilastatin is a dehydropeptidase inhibitor. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Infection |
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| Target | Dehydropeptidase[1] |
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| References | [1]. The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterialmetallo-beta-lactamase enzyme CphA. Antimicrob Agents Chemother. 1995 Jul;39(7):1629-31. |
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Chemical & Physical Properties
| Density | 1.275 g/cm3 |
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| Boiling Point | 655.5ºC at 760 mmHg |
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| Melting Point | 156-158ºC |
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| Molecular Formula | C16H26N2O5S |
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| Molecular Weight | 358.45300 |
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| Exact Mass | 358.15600 |
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| PSA | 155.02000 |
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| LogP | 2.52380 |
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| Index of Refraction | 1.569 |
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| InChIKey | DHSUYTOATWAVLW-ZOINEBSPSA-N |
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| SMILES | CC1(C)CC1C(=O)NC(=CCCCCSCC(N)C(=O)O)C(=O)O |
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| Storage condition | -20°C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MJ9650100
- CHEMICAL NAME :
- 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyc lopropyl)carbonyl) amino)-, (R-(R*,S*-(Z)))-
- CAS REGISTRY NUMBER :
- 82009-34-5
- LAST UPDATED :
- 198706
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C16-H26-N2-O5-S
- MOLECULAR WEIGHT :
- 358.50
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHINDQ Pharmacy International. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1980- Volume(issue)/page/year: 5,133,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHINDQ Pharmacy International. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1980- Volume(issue)/page/year: 5,133,1984
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36 |
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| WGK Germany | 3 |
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Synonyms
| EINECS 279-875-8 |
| Cilastatin acid |
| Cilastatine [French] |
| Cilastatinum |
| Cilastatine |
| Cilastatin |
| Cilastatin Monosodium Salt |
| Cilastatina [Spanish] |
| (Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid |
| MFCD01723686 |
| Cilastatinum [Latin] |
| [R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid |
| Cilastatina |
| (Z)-7-[(2R)-(2-amino-2-carboxyethyl)thio]-2-((1S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid |
