Introduction：Basic information about CAS 79580-28-2|Brevetoxin2(PbTx-2), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Brevetoxin2(PbTx-2) |
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| CAS Number | 79580-28-2 | Molecular Weight | 895.08200 |
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| Density | 1.188g/cm3 | Boiling Point | / |
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| Molecular Formula | C50H70O14 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | brevetoxin b |
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| Synonym | More Synonyms |
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Brevetoxin2(PbTx-2) BiologicalActivity
| Description | Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium Channel |
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Chemical & Physical Properties
| Density | 1.188g/cm3 |
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| Molecular Formula | C50H70O14 |
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| Molecular Weight | 895.08200 |
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| Exact Mass | 894.47700 |
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| PSA | 155.90000 |
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| LogP | 5.47210 |
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| Index of Refraction | 1.522 |
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| InChIKey | LYTCVQQGCSNFJU-FGRVLNGBSA-N |
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| SMILES | C=C(C=O)CC1CC(O)C2(C)OC3CC4OC5CC6(C)OC7(C)CCC8OC9CC%10(C)OC%11C(C)=CC(=O)OC%11CC%10OC9CC(C)C8OC7CC6OC5(C)CC=CC4OC3CC2O1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- XW5886000
- CHEMICAL NAME :
- Toxin T-34
- CAS REGISTRY NUMBER :
- 79580-28-2
- LAST UPDATED :
- 198909
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C50-H70-O14
- MOLECULAR WEIGHT :
- 895.20
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6600 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
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Safety Information
| Hazard Codes | T+: Very toxic; |
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| Risk Phrases | 26/27/28 |
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| Safety Phrases | 22-36/37/39-45 |
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| RIDADR | UN 2811 6.1/PG 2 |
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| Hazard Class | 6.1(a) |
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Synonyms
| brevetoxin-B |
| gb2 |
| btx-b |
| PBTX-2 |
| toxint-34 |
| t4-7 |
| GBTX-2 |
| t4-7toxin |
| gb2toxin |
| BREVETOXIN 2 |
