CAS 82436-77-9|BS3 Crosslinker
| Common Name | BS3 Crosslinker | ||
|---|---|---|---|
| CAS Number | 82436-77-9 | Molecular Weight | 550.447 |
| Density | / | Boiling Point | / |
| Molecular Formula | C16H20N2O14S2 | Melting Point | >300°C |
| MSDS | USA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1-[8-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-8-oxooctanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid |
|---|---|
| Synonym | More Synonyms |
BS3 Crosslinker BiologicalActivity
| Description | BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
| Target | Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
Chemical & Physical Properties
| Melting Point | >300°C |
|---|---|
| Molecular Formula | C16H20N2O14S2 |
| Molecular Weight | 550.447 |
| Exact Mass | 550.017517 |
| PSA | 255.69000 |
| Appearance of Characters | powder |
| InChIKey | VYLDEYYOISNGST-UHFFFAOYSA-N |
| SMILES | O=C(CCCCCCC(=O)ON1C(=O)CC(S(=O)(=O)O)C1=O)ON1C(=O)CC(S(=O)(=O)O)C1=O |
| Storage condition | −20°C |
| Water Solubility | H2O: 10 mg/mL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | - |
Articles188
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| Toll-Like Receptor 9 Alternatively Spliced Isoform Negatively Regulates TLR9 Signaling in Teleost Fish. PLoS ONE 10 , e0126388, (2015) Toll-like receptor 9 (TLR9) recognizes and binds unmethylated CpG motifs in DNA, which are found in the genomes of bacteria and DNA viruses. In fish, Tlr9 is highly diverse, with the number of introns... | |
| Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure. Nucleic Acids Res. 43 , 3033-45, (2015) Despite insights on the cellular level, the molecular details of chromatin reorganization in sperm development, which involves replacement of histone proteins by specialized factors to allow ultra mos... |
Synonyms
| Bis(sulfosuccinimidyl)suberate(BS3(Sulfo-DSS)) |
| 3-Pyrrolidinesulfonic acid, 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis[2,5-dioxo-, sodium salt (1:1) |
| BS(3) Cpd |
| MFCD00054982 |
| 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis(2,5-dioxo-3-pyrrolidinesulfonic acid) |
| Bis(sulfosuccinimidyl) suberate sodium salt |
| BSSIS |
| bis(sulfosuccinimidyl)suberate |
| Disulfosuccinimidyl suberate |
| Sodium 1-({8-[(2,5-dioxo-3-sulfo-1-pyrrolidinyl)oxy]-8-oxooctanoyl}oxy)-2,5-dioxo-3-pyrrolidinesulfonate |
