CAS 92-84-2|Phenothiazine

[1]. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35.

[2]. Ohlow MJ, et, al. Phenothiazine: the seven lives of pharmacology's first lead structure. Drug Discov Today. 2011 Feb;16(3-4):119-31.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SN5075000

CHEMICAL NAME :

Phenothiazine

CAS REGISTRY NUMBER :

92-84-2

BEILSTEIN REFERENCE NO. :

0143237

LAST UPDATED :

199712

DATA ITEMS CITED :

28

MOLECULAR FORMULA :

C12-H9-N-S

MOLECULAR WEIGHT :

199.28

WISWESSER LINE NOTATION :

T C666 BM ISJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

425 mg/kg/5D

TOXIC EFFECTS :

Behavioral - headache Liver - jaundice, other or unclassified Blood - normocytic anemia

REFERENCE :

LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 242,86,1942

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Behavioral - antipsychotic

REFERENCE :

DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

178 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00586

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - cattle

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Bird - wild bird species

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 66,888,1944 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1250 mg/kg

SEX/DURATION :

female 1-22 day(s) after conception

REFERENCE :

AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 6,160,1975 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,204,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENOTHIAZINE-air:10H TWA 5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84116 No. of Facilities: 175 (estimated) No. of Industries: 5 No. of Occupations: 15 No. of Employees: 5639 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84116 No. of Facilities: 5473 (estimated) No. of Industries: 54 No. of Occupations: 68 No. of Employees: 88048 (estimated) No. of Female Employees: 8791 (estimated)

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