CAS 58293-56-4|9-(2,2-Dicyanovinyl)julolidine

Introduction：Basic information about CAS 58293-56-4|9-(2,2-Dicyanovinyl)julolidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 9-(2,2-Dicyanovinyl)julolidine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles14
7. Synonyms

Common Name	9-(2,2-Dicyanovinyl)julolidine
CAS Number	58293-56-4	Molecular Weight	249.31000
Density	1.23 g/cm3	Boiling Point	470.7ºC at 760 mmHg
Molecular Formula	C₁₆H₁₅N₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	214.6ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	9-(2,2-Dicyanovinyl)julolidine
Synonym	More Synonyms

9-(2,2-Dicyanovinyl)julolidine BiologicalActivity

Description	DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288. [2]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288.

Description

DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells[1].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288.

[2]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288.

Chemical & Physical Properties

Density	1.23 g/cm3
Boiling Point	470.7ºC at 760 mmHg
Molecular Formula	C₁₆H₁₅N₃
Molecular Weight	249.31000
Flash Point	214.6ºC
Exact Mass	249.12700
PSA	50.82000
LogP	2.88096
Index of Refraction	1.634
InChIKey	LROAUBRDKLVBCP-UHFFFAOYSA-N
SMILES	N#CC(C#N)=Cc1cc2c3c(c1)CCCN3CCC2

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO4445000

CHEMICAL NAME :: Malononitrile, (2,3,6,7-tetrahydro-1H,5H-benzo(ij)quinolizin-9-ylmet hylene)-

CAS REGISTRY NUMBER :: 58293-56-4

BEILSTEIN REFERENCE NO. :: 0240710

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H15-N3

MOLECULAR WEIGHT :: 249.34

WISWESSER LINE NOTATION :: T666 1A M BNT&TJ H1UYCN&CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#08444

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
RTECS	OO4445000

Articles14

Fluorescent molecular rotors: a new class of probes for tubulin structure and assembly.

Biochemistry 28 , 6678, (1989)

9-(Dicyanovinyl)julolidine (DCVJ) is a fluorescent dye whose intramolecular rotational relaxation is solvent dependent. Since its quantum yield increases with decreasing free volume, this molecule has...

9-(Dicyanovinyl)julolidine binding to bovine brain calmodulin.

J. Biochem. 109 , 499, (1991)

A molecular rotor, 9-(dicyanovinyl)julolidine (DCVJ), is a fluorescent dye whose intramolecular rotation determines its fluorescence yield [Kung, C.E. & Reed, J.K. (1989) Biochemistry 28, 6678-6686]. ...

Antibodies for fluorescent molecular rotors.

Biochemistry 32 , 7589, (1993)

We have prepared monoclonal antibodies for the fluorescent molecular rotors 9-(2-carboxy-2-cyanovinyl)julolidine (CCVJ) and 9-(dicyanovinyl)julolidine (DCVJ). Mouse monoclonal antibody (IgG2b) prepare...

Synonyms

dcvj

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