CAS 452-06-2|2-Aminopurine
| Common Name | 2-Aminopurine | ||
|---|---|---|---|
| CAS Number | 452-06-2 | Molecular Weight | 135.127 |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 328.2±25.0 °C at 760 mmHg |
| Molecular Formula | C5H5N5 | Melting Point | 280-282 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 152.3±23.2 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-aminopurine |
|---|---|
| Synonym | More Synonyms |
2-Aminopurine BiologicalActivity
| Description | 2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | 2-Aminopurine (2AP) is not valuable as afluorescent label because its fluorescence is highly quenched by stacking with the natural bases, when it is inserted in anoligonucleotide. However, it is this very susceptibility to interbase quenching that makes 2AP an exquisitely sensitivefluorescent probe of nucleic acid structure[1]. 2-Aminopurine differs from adenine (6-aminopurine) only in the position of the exocyclic amine group, and yet its fluorescence intensity is one thousand times that of adenine[1]. |
| References | [1]. J M Jean, et al. 2-Aminopurine fluorescence quenching and lifetimes: role of base stacking. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):37-41. [2]. Dehong Tan, et al. Decreased glycation and structural protection properties of γ-glutamyl-S-allyl-cysteine peptide isolated from fresh garlic scales (Allium sativum L.). Nat Prod Res. 2015;29(23):2219-22. |
Chemical & Physical Properties
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 328.2±25.0 °C at 760 mmHg |
| Melting Point | 280-282 °C(lit.) |
| Molecular Formula | C5H5N5 |
| Molecular Weight | 135.127 |
| Flash Point | 152.3±23.2 °C |
| Exact Mass | 135.054489 |
| PSA | 80.48000 |
| LogP | -1.33 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.954 |
| InChIKey | MWBWWFOAEOYUST-UHFFFAOYSA-N |
| SMILES | Nc1ncc2[nH]cnc2n1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 723 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 270 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Specific locus test
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 78,5685,1981
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 78,5685,1981
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S22-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UO7475000 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Aminoperin |
| iso-Adenine |
| 2-Aminopurine |
| 3H-Purin-2-amine |
| MFCD07357244 |
| 7H-Purin-2-amine |
| 9H-Purin-2-amine |
| 2-amino purine |
| EINECS 207-197-4 |
| 9H-purin-2-ylamine |
| Purine, 2-amino- |
| 2-amino-6-purine |
| 1H-Purin-2-amine |
| 4-aminopurine |
| 2-amino-purin |
| SQ 22,451 |
