Introduction：Basic information about CAS 77-37-2|1-Pyrrolidinepropanol, a-cyclohexyl-a-phenyl-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Pyrrolidinepropanol, a-cyclohexyl-a-phenyl- |
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| CAS Number | 77-37-2 | Molecular Weight | 287.44000 |
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| Density | 1.057 g/cm3 | Boiling Point | 433.5ºC at 760 mmHg |
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| Molecular Formula | C19H29NO | Melting Point | 85.5-86.5° |
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| MSDS | / | Flash Point | 205.7ºC |
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Names
| Name | procyclidine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRSignaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| In Vivo | Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1]. Animal Model: Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1] Dosage: 0.3-6.0 mg/kg Administration: Subcutaneous injection; once Result: Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively. Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus. |
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| References | [1]. Yun-Bae Kim, et al. Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. Environ Toxicol Pharmacol. 2002 Jan;11(1):15-21. [2]. Ulrich Ettinger, et al. Effects of procyclidine on eye movements in schizophrenia. Neuropsychopharmacology. 2003 Dec;28(12):2199-208. |
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Chemical & Physical Properties
| Density | 1.057 g/cm3 |
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| Boiling Point | 433.5ºC at 760 mmHg |
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| Melting Point | 85.5-86.5° |
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| Molecular Formula | C19H29NO |
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| Molecular Weight | 287.44000 |
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| Flash Point | 205.7ºC |
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| Exact Mass | 287.22500 |
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| PSA | 23.47000 |
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| LogP | 3.87830 |
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| Index of Refraction | 1.554 |
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| InChIKey | WYDUSKDSKCASEF-UHFFFAOYSA-N |
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| SMILES | OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UY1925000
- CHEMICAL NAME :
- 1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-
- CAS REGISTRY NUMBER :
- 77-37-2
- BEILSTEIN REFERENCE NO. :
- 0088563
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H29-N-O
- MOLECULAR WEIGHT :
- 287.49
- WISWESSER LINE NOTATION :
- T5NTJ A2XQR&- AL6TJ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 131 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,291,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,291,1972
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Synonyms
| Kemadrine |
| Arpicolin |
| Procyklidin |
| Spamol |
| 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol |
| 1-Cyclohexyl-3-pyrrolidino-1-phenyl-propan-1-ol |
| Lergine |
| Elorine |
| 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol |
| Triciclidina |
| tricyclamol |
| Osnervan |
| 1-Cyclohexyl-1-phenyl-3-pyrrolidino-propan-1-ol |
