CAS 1775-97-9|Flavokawain B

Introduction：Basic information about CAS 1775-97-9|Flavokawain B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Flavokawain B BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Flavokawain B
CAS Number	1775-97-9	Molecular Weight	284.306
Density	1.203±0.06 g/cm3	Boiling Point	500.1±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆O₄	Melting Point	178-179 ºC (ethanol )
MSDS	/	Flash Point	185.8±23.6 °C

Names

Name	4',6'-dimethoxy-2'-hydroxychalcone
Synonym	More Synonyms

Flavokawain B BiologicalActivity

Description	Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer
References	[1]. Rossette MC, et al. The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. Phytother Res. 2017 Oct;31(10):1607-1613. [2]. Li X, et al. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 Mar 18;17(1):25.

Description

Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer

References

[1]. Rossette MC, et al. The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. Phytother Res. 2017 Oct;31(10):1607-1613.

[2]. Li X, et al. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 Mar 18;17(1):25.

Chemical & Physical Properties

Density	1.203±0.06 g/cm3
Boiling Point	500.1±50.0 °C at 760 mmHg
Melting Point	178-179 ºC (ethanol )
Molecular Formula	C₁₇H₁₆O₄
Molecular Weight	284.306
Flash Point	185.8±23.6 °C
Exact Mass	284.104858
PSA	55.76000
LogP	4.01
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.614
InChIKey	QKQLSQLKXBHUSO-CMDGGOBGSA-N
SMILES	COc1cc(O)c(C(=O)C=Cc2ccccc2)c(OC)c1
Storage condition	-20℃
Water Solubility	Practically insoluble (0.012 g/L) (25 ºC)

Safety Information

HS Code	2914509090

Customs

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Synonyms

(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one

CARDAMONIN-4'-METHYL ETHER

2'-Hydroxy-4',6'-dimethoxychalcone

2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-

flavokawin B

(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one

(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one

1OR CQ EO1 BV1U1R &&E Form

MFCD00075877

DIMETHOXY-2'-HYDROXYCHALCONE,4',6'

Flavokawain B

Flavokavain B

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