Introduction：Basic information about CAS 343-27-1|Harmine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Harmine hydrochloride |
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| CAS Number | 343-27-1 | Molecular Weight | 248.708 |
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| Density | / | Boiling Point | 421.4ºC at 760mmHg |
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| Molecular Formula | C13H13ClN2O | Melting Point | 265-270°C |
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| MSDS | / | Flash Point | 139.8ºC |
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Names
| Name | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride |
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| Synonym | More Synonyms |
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Harmine hydrochloride BiologicalActivity
| Description | Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>DYRK |
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| Target | Ki: 397 nM (5-HT2A serotonin receptor)[1], DYRK1A[2] |
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| In Vitro | Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine[3]. |
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| In Vivo | It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4]. |
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| References | [1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91. |
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Chemical & Physical Properties
| Boiling Point | 421.4ºC at 760mmHg |
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| Melting Point | 265-270°C |
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| Molecular Formula | C13H13ClN2O |
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| Molecular Weight | 248.708 |
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| Flash Point | 139.8ºC |
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| Exact Mass | 248.071640 |
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| PSA | 37.91000 |
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| LogP | 3.83510 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MG9450000
- CHEMICAL NAME :
- Harmine, hydrochloride
- CAS REGISTRY NUMBER :
- 343-27-1
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C13-H12-N2-O.Cl-H
- MOLECULAR WEIGHT :
- 248.73
- WISWESSER LINE NOTATION :
- T B656 EN HMJ F1 KO1 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,127,1943
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S22-S36 |
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| RIDADR | 1544 |
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| WGK Germany | 3 |
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| RTECS | MG9450000 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 7-Methoxy-1-methyl-9H-β-carbolinhydrochlorid |
| 7-Methoxy-1-methyl-9H-β-carboline hydrochloride |
| Harmine.HCL |
| EINECS 206-443-8 |
| Harmine hydrochloride hydrate |
| Harmine monohydrochloride |
| MFCD00012641 |
| 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, monohydrochloride |
| HARMINE HYDROCHLORIDE |
| 7-Methoxy-1-methyl-9H-β-carboline hydrochloride (1:1) |
| 7-Méthoxy-1-méthyl-9H-β-carboline chlorhydrate |
| 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, hydrochloride (1:1) |
| Banisterine Hydrochloride |
