CAS 65182-56-1|3-amino-2-chloro-6-(trifluoromethyl)pyridine
| Common Name | 3-amino-2-chloro-6-(trifluoromethyl)pyridine | ||
|---|---|---|---|
| CAS Number | 65182-56-1 | Molecular Weight | 222.24200 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H10N2O | Melting Point | 92-94ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | 6-(1H-1,8-naphthyridin-2-ylidene)cyclohexa-2,4-dien-1-one |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATResearch Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>STAT |
| References | [1]. Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61. |
Chemical & Physical Properties
| Melting Point | 92-94ºC |
|---|---|
| Molecular Formula | C14H10N2O |
| Molecular Weight | 222.24200 |
| Exact Mass | 222.07900 |
| PSA | 46.01000 |
| LogP | 3.00240 |
| Appearance of Characters | orange |
| InChIKey | AYKMXKNVEUMLFQ-UHFFFAOYSA-N |
| SMILES | Oc1ccccc1-c1ccc2cccnc2n1 |
| Storage condition | room temp |
| Water Solubility | DMSO: ≥10mg/mL |
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| Hazard Codes | Xn,T |
| Risk Phrases | 22-41-36-25 |
| Safety Phrases | 26-39-45 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-<o-Hydroxy-phenyl>-1,8-naphthyridin |
