CAS 92321-29-4|2-Phenyl-2-(1-piperidinyl)propane
Introduction：Basic information about CAS 92321-29-4|2-Phenyl-2-(1-piperidinyl)propane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Phenyl-2-(1-piperidinyl)propane | ||
|---|---|---|---|
| CAS Number | 92321-29-4 | Molecular Weight | 300.37200 |
| Density | 0.969g/cm3 | Boiling Point | 271.1ºC at 760 mmHg |
| Molecular Formula | C17H16O3S | Melting Point | / |
| MSDS | / | Flash Point | 107.6ºC |
Names
| Name | 1-(2-phenylpropan-2-yl)piperidine |
|---|---|
| Synonym | More Synonyms |
2-Phenyl-2-(1-piperidinyl)propane BiologicalActivity
| Description | 2-Phenyl-2-(1-piperidinyl)propane is a selective and reversible human CYP2B6 inhibitor with an IC50 of 5.1 μM and a Ki of 5.6. 2-Phenyl-2-(1-piperidinyl)propane inhibits CYP2D6 (IC50=74 μM), CYP3A (IC50=200 μM)[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Research Areas >>Metabolic Disease |
| Target | CYP2B6:5.1 μM (IC50) CYP2B6:5.6 μM (Ki) CYP2D6:74 μM (IC50) CYP3A:200 μM (IC50) CYP1A2:>300 μM (IC50) CYP2A6:>300 μM (IC50) CYP2C8:>300 μM (IC50) CYP2C9:>300 μM (EC50) CYP2C19:>300 μM (IC50) CYP2E1:>300 μM (IC50) |
| References | [1]. Walsky RL, et al. A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos. 2007 Nov;35(11):2053-9. |
Chemical & Physical Properties
| Density | 0.969g/cm3 |
|---|---|
| Boiling Point | 271.1ºC at 760 mmHg |
| Molecular Formula | C17H16O3S |
| Molecular Weight | 300.37200 |
| Flash Point | 107.6ºC |
| Exact Mass | 300.08200 |
| PSA | 68.67000 |
| LogP | 3.97700 |
| Index of Refraction | 1.528 |
| InChIKey | HORGQLWAZQOQNU-UHFFFAOYSA-N |
| SMILES | CC(C)(c1ccccc1)N1CCCCC1 |
| Storage condition | 2-8°C |
Safety Information
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| N-<1-Methyl-1-phenyl-aethyl>-piperidin |
