Introduction：Basic information about CAS 3316-02-7|ζ-Stat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ζ-Stat |
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| CAS Number | 3316-02-7 | Molecular Weight | 384.36000 |
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| Density | 2.019g/cm3 | Boiling Point | / |
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| Molecular Formula | C10H8O10S3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 8-hydroxynaphthalene-1,3,6-trisulfonic acid |
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| Synonym | More Synonyms |
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ζ-Stat BiologicalActivity
| Description | ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>PKCSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>TGF-beta/Smad >>PKC |
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| Target | aPKC-ζ:5 μM (IC50) |
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| In Vitro | ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1]. ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1]. ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2]. ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1]. ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1]. Cell Proliferation Assay[1] Cell Line: MEL-F-NEO, SK-MEL-2 and MeWo cells Concentration: 0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM Incubation Time: 3 days Result: Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells. Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM. Western Blot Analysis[1] Cell Line: SK-MEL-2 and MeWo cells Concentration: 5 µM Incubation Time: 3 days Result: Decreased phosphorylated and total PKC-ζ levels. |
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| References | [1]. Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. [2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665. |
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Chemical & Physical Properties
| Density | 2.019g/cm3 |
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| Molecular Formula | C10H8O10S3 |
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| Molecular Weight | 384.36000 |
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| Exact Mass | 383.92800 |
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| PSA | 208.48000 |
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| LogP | 3.52790 |
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| Index of Refraction | 1.741 |
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| InChIKey | KMXMLAGYNHELHA-UHFFFAOYSA-N |
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| SMILES | O=S(=O)(O)c1cc(O)c2c(S(=O)(=O)O)cc(S(=O)(=O)O)cc2c1 |
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Safety Information
Customs
| HS Code | 2908999090 |
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| Summary | 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 1-Naphthol,6,8-trisulfo |
| 1-naphthol-3,6,8-trisulfonic acid |
| 8-Hydroxy-naphthalin-1,3,6-trisulfonsaeure |
| 8-hydroxy-naphthalene-1,3,6-trisulfonic acid |
| 1-Naphthol,3,6,8-trisulfo |
| Naphthol-(1)-trisulfonsaeure-(3.6.8) |
| 1-naphthol-3,6,8-trisulphonic acid |
| 1-Naphthylamin-3,6,8-trisulfonsaeure |
