CAS 644-78-0|2-Hydroxychalcone

Introduction：Basic information about CAS 644-78-0|2-Hydroxychalcone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2-Hydroxychalcone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	2-Hydroxychalcone
CAS Number	644-78-0	Molecular Weight	224.25500
Density	1.191g/cm3	Boiling Point	396.566ºC at 760 mmHg
Molecular Formula	C₁₅H₁₂O₂	Melting Point	144-150ºC(lit.)
MSDS	/	Flash Point	169.35ºC

Names

Name	2-Hydroxychalcone
Synonym	More Synonyms

2-Hydroxychalcone BiologicalActivity

Description	2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
Related Catalog	Signaling Pathways >>Apoptosis >>Bcl-2 FamilySignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Metabolic Disease
In Vitro	2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1]. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].
References	[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

Chemical & Physical Properties

Density	1.191g/cm3
Boiling Point	396.566ºC at 760 mmHg
Melting Point	144-150ºC(lit.)
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.25500
Flash Point	169.35ºC
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830
Index of Refraction	1.654

Safety Information

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
HS Code	2914501900

Customs

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Synonyms

3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one

EINECS 211-422-1

MFCD00016449

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