CAS 977-96-8|1,1'-Diethyl-2,2'-cyanine iodide

Introduction：Basic information about CAS 977-96-8|1,1'-Diethyl-2,2'-cyanine iodide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 1,1'-Diethyl-2,2'-cyanine iodide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles25
6. Synonyms

Common Name	1,1'-Diethyl-2,2'-cyanine iodide
CAS Number	977-96-8	Molecular Weight	454.34700
Density	/	Boiling Point	/
Molecular Formula	C₂₃H₂₃IN₂	Melting Point	273ºC
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS06	Signal Word	Danger

Names

Name	1,1'-diethyl-2,2'-cyanine iodide
Synonym	More Synonyms

1,1'-Diethyl-2,2'-cyanine iodide BiologicalActivity

Description	Pseudoisocyanine (iodide) is a pan inhibitor of monoamine transporters and organic cation transporters with antidepressant-like activity[1].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Dopamine TransporterResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>Serotonin TransporterSignaling Pathways >>Membrane Transporter/Ion Channel >>Monoamine Transporter
References	[1]. Fraser-Spears R, et al. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. Eur J Pharmacol. 2019 Jan 5;842:351-364.

Chemical & Physical Properties

Melting Point	273ºC
Molecular Formula	C₂₃H₂₃IN₂
Molecular Weight	454.34700
Exact Mass	454.09100
PSA	8.81000
LogP	1.23570
InChIKey	GMYRVMSXMHEDTL-UHFFFAOYSA-M
SMILES	CCN1C(=Cc2ccc3ccccc3[n+]2CC)C=Cc2ccccc21.[I-]

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H330-H312-H315-H319-H335
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R23/24/25
Safety Phrases	45
RIDADR	UN 2811
Packaging Group	II
Hazard Class	6.1(a)

Articles25

Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression.

J. Neurosci. 33(25) , 10534-43, (2013)

Mood disorders cause much suffering and lost productivity worldwide, compounded by the fact that many patients are not effectively treated by currently available medications. The most commonly prescri...

Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells.

Inflamm. Res. 58 Suppl 1 , 61-2, (2009)

Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus.

Brain Res. 1063(1) , 69-76, (2005)

In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not ...

Synonyms

1,1'-DIETHYL-2,2'-CYANINE IODIDE

EINECS 213-556-6

MFCD00011971

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