Introduction：Basic information about CAS 78510-02-8|1-Octanol-d2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Octanol-d2 |
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| CAS Number | 78510-02-8 | Molecular Weight | 132.24000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C8H16D2O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-octanol-1,1-d2 |
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| Synonym | More Synonyms |
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1-Octanol-d2 BiologicalActivity
| Description | 1-Octanol-d2 is the deuterium labeled 1-Octanol[1]. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[2]. 1-Octanol is a highly attractive biofuel with diesel-like properties[3]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium Channel |
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| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
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| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Joksovic PM, et al. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94. [3]. Akhtar MK, et al. Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties. Metab Eng Commun. 2014 Nov 132:1-5. |
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Chemical & Physical Properties
| Molecular Formula | C8H16D2O |
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| Molecular Weight | 132.24000 |
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| Exact Mass | 132.14800 |
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| PSA | 20.23000 |
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| LogP | 2.33920 |
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| InChIKey | KBPLFHHGFOOTCA-MGVXTIMCSA-N |
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| SMILES | CCCCCCCCO |
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Synonyms
| 1-octanol-1-(2)H2 |
| 1-[1,1-D2]octanol |
| 1-[1,1-(2)H2]-octanol |
| <1-2H2>-1-octanol |
| (2H2)ethane |
| <1,1-2H2>octanol |
