Introduction：Basic information about CAS 183320-51-6|OSI-420, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | OSI-420 |
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| CAS Number | 183320-51-6 | Molecular Weight | 415.870 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H22ClN3O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol,hydrochloride |
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| Synonym | More Synonyms |
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OSI-420 BiologicalActivity
| Description | Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor. |
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| Related Catalog | Research Areas >>Cancer |
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| In Vivo | Desmethyl Erlotinib exposure (AUC) in plasma is 30% (range 12-59%) of erlotinib, and Desmethyl Erlotinib clearance is more than 5-fold higher than erlotinib. The CSF penetration of erlotinib and Desmethyl Erlotinib is <5% relative to total plasma concentration[1]. |
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| References | [1]. Meany HJ, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008, 62(3), 387-392. |
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Chemical & Physical Properties
| Molecular Formula | C21H22ClN3O4 |
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| Molecular Weight | 415.870 |
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| Exact Mass | 415.129883 |
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| PSA | 85.73000 |
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| LogP | 3.62600 |
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| InChIKey | BUOXOWNQZVIETJ-UHFFFAOYSA-N |
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| SMILES | C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCO)cc23)c1.Cl |
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| Storage condition | -20℃ |
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Synonyms
| OSI-420 |
| 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl}oxy)ethanol hydrochloride (1:1) |
| Desmethyl erlotinib hydrochloride |
| Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride (1:1) |
| S2205_Selleck |
| Desmethyl Erlotinib |
| Erlotinib Impurity 4 |
