CAS 108395-15-9|2-Ketoglutaric acid-13C

Introduction：Basic information about CAS 108395-15-9|2-Ketoglutaric acid-13C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2-Ketoglutaric acid-13C BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	2-Ketoglutaric acid-13C
CAS Number	108395-15-9	Molecular Weight	147.09
Density	/	Boiling Point	/
Molecular Formula	C₄₁₃CH₆O₅	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	2-Ketoglutaric Acid-13C1
Synonym	More Synonyms

2-Ketoglutaric acid-13C BiologicalActivity

Description	2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636)[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2][3].
Related Catalog	Research Areas >>Others
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

Description

2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636)[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2][3].

Related Catalog

Research Areas >>Others

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.

[2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.

[3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

Chemical & Physical Properties

Molecular Formula	C₄₁₃CH₆O₅
Molecular Weight	147.09
Exact Mass	147.02500
PSA	91.67000

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
RIDADR	NONH for all modes of transport

Synonyms

2-oxopentanedioic acid

2-Ketopentanedioic acid-1-13C,2-Oxopentanedioic acid-1-13C

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