CAS 6305-43-7|2,3-Butanedione,1,4-dibromo-

CHEMICAL IDENTIFICATION

RTECS NUMBER :

EK2850000

CHEMICAL NAME :

2,3-Butanedione, 1,4-dibromo-

CAS REGISTRY NUMBER :

6305-43-7

BEILSTEIN REFERENCE NO. :

0970154

LAST UPDATED :

199707

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C4-H4-Br2-O2

MOLECULAR WEIGHT :

243.90

WISWESSER LINE NOTATION :

E1VV1E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

9400 ug/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Nutritional and Gross Metabolic - other changes

REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 31,297,1963

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

10 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00598

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

21 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse

REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 31,297,1963

Chem. Commun. (Camb.) (15) , 1999-2001, (2009)

Reaction of a pinene-based pyridylthioamide with 1,4-dibromo-2,3-butanedione in refluxing methanol yielded a new chiral pyridylthiazole ligand L which forms a dinuclear double-stranded helicate with C...

Protein Sci. 1(5) , 678-87, (1992)

The bifunctional reagent 1,4-dibromobutanedione (DBBD) reacts covalently with pyruvate kinase from rabbit muscle to cause inactivation of the enzyme at a rate that is linearly dependent on the reagent...