CAS 455-14-1|4-Aminobenzotrifluoride
Introduction：Basic information about CAS 455-14-1|4-Aminobenzotrifluoride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Aminobenzotrifluoride | ||
|---|---|---|---|
| CAS Number | 455-14-1 | Molecular Weight | 161.124 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 190.0±40.0 °C at 760 mmHg |
| Molecular Formula | C7H6F3N | Melting Point | 3-8 °C |
| MSDS | ChineseUSA | Flash Point | 86.7±0.0 °C |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | 4-trifluoromethylaniline |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 190.0±40.0 °C at 760 mmHg |
| Melting Point | 3-8 °C |
| Molecular Formula | C7H6F3N |
| Molecular Weight | 161.124 |
| Flash Point | 86.7±0.0 °C |
| Exact Mass | 161.045227 |
| PSA | 26.02000 |
| LogP | 1.95 |
| Vapour Pressure | 0.6±0.4 mmHg at 25°C |
| Index of Refraction | 1.478 |
| InChIKey | ODGIMMLDVSWADK-UHFFFAOYSA-N |
| SMILES | Nc1ccc(C(F)(F)F)cc1 |
| Storage condition | Refrigerator, Under Inert Atmosphere |
| Water Solubility | <0.1 g/100 mL |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 101 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 58 mg/kg/3D-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,803,1983
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,803,1983
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319-H410 |
| Precautionary Statements | P273-P301 + P310-P305 + P351 + P338-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R20/21/22;R33;R36/37/38 |
| Safety Phrases | S26-S45-S60-S61-S36/37/39 |
| RIDADR | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | XU9260000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 29214300 |
Customs
| HS Code | 2921420090 |
|---|---|
| Summary | HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles29
More Articles| The many roles for fluorine in medicinal chemistry. J. Med. Chem. 51 , 4359-69, (2008) | |
| Trifluoromethylanilines--their effect on DNA synthesis and proliferative activity in parenchymal organs of rats. Toxicology 83(1-3) , 49-59, (1993) Reactive isomeric 3- and 4-trifluoromethylanilines (3-,4-TFMA), and control aniline itself, induced the following effects on biosynthesis of DNA in the liver, kidney, thymus and spleen of rats: (a) Th... | |
| Effects of trifluoromethylaniline isomers on enzyme activities in lymphatic organs and hematology of the rat. Toxicology 92(1-3) , 27-38, (1994) Three isomers of trifluoromethylaniline (TFMA) were investigated for their possible different toxic effects on the hematopoietic system in male Wistar rats. The effects of isomeric 2-, 3- and 4-TFMA w... |
Synonyms
| 4-aminotrifluorotoluene |
| MFCD00064396 |
| α,α,α-Trifluoro-p-toluidine |
| TRIFLUOROMETHYLANILINE |
| 4-Aminobenzotrifluororide |
| 4-AMINOBENZOTRIFLOURIDE |
| p-trifluoromethylphenylamine |
| para-trifluoromethylaniline |
| 4-trifluoromethylphenylamine |
| 4-Aminobenzotrifluoride |
| 4-(trifluoromethyl)aniline |
| aminobenzotrifluoride |
| EINECS 207-236-5 |
| P-AMINOBENZOTRIFLUORIDE |
| Leflunomide Impurity 1 |
