CAS 3482-37-9|Trimethylcolchicinic acid
Introduction：Basic information about CAS 3482-37-9|Trimethylcolchicinic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trimethylcolchicinic acid | ||
|---|---|---|---|
| CAS Number | 3482-37-9 | Molecular Weight | 343.37400 |
| Density | 1.32g/cm3 | Boiling Point | 629ºC at 760mmHg |
| Molecular Formula | C19H21NO5 | Melting Point | >230ºC (dec.) |
| MSDS | ChineseUSA | Flash Point | 334.2ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N-Deacetyl Colchiceine |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.32g/cm3 |
|---|---|
| Boiling Point | 629ºC at 760mmHg |
| Melting Point | >230ºC (dec.) |
| Molecular Formula | C19H21NO5 |
| Molecular Weight | 343.37400 |
| Flash Point | 334.2ºC |
| Exact Mass | 343.14200 |
| PSA | 91.01000 |
| LogP | 3.09150 |
| Index of Refraction | 1.628 |
| InChIKey | IRVWPZRYDQROLU-ZDUSSCGKSA-N |
| SMILES | COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1C(N)CC2 |
| Storage condition | −20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- REFERENCE :
- CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- REFERENCE :
- CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20/21/22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | GH0960000 |
Articles5
More Articles| Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid. Basic Clin Pharmacol Toxicol. 96(5) , 375-80, (2005) The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid ... | |
| Effect of colchicine and trimethylcolchicinic acid on CCl4-induced cirrhosis in the rat. Pharmacol. Toxicol. 79(5) , 241-6, (1996) Colchicine is one of the most promising drugs for the treatment of cirrhosis. However, due to its toxicity, other drugs are being evaluated and colchicine-like molecules may be good alternatives. The ... | |
| The role of microtubules in pinocytosis. Inhibition of fluid-phase pinocytosis in the rat visceral yolk sac by mitoclasic and related agents. Cell Biol. Int. Rep. 7(8) , 593-602, (1983) Colchicine, demecolcine and vinblastine all effectively inhibited the pinocytic capture of 125I-labelled poly(vinylpyrrolidone) by rat visceral yolk sacs cultured in vitro. Complete inhibition did not... |
Synonyms
| trimethylcolchicinic acid |
