CAS 79498-31-0|Glaucocalyxin A

Introduction：Basic information about CAS 79498-31-0|Glaucocalyxin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameGlaucocalyxin A
CAS Number79498-31-0Molecular Weight332.434
Density1.2±0.1 g/cm3Boiling Point513.4±50.0 °C at 760 mmHg
Molecular FormulaC20H28O4Melting Point219.5-220.5℃
MSDS/Flash Point278.4±26.6 °C

Names

Nameent-7β,14α-Dihydroxy-16-kauren-3,15-dione
SynonymMore Synonyms

Glaucocalyxin A BiologicalActivity

DescriptionGlaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].
Related CatalogSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>PI3K/Akt/mTOR >>Akt
Target

PI3K

Akt

In VitroGlaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].
References

[1]. Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9(6):708.

Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point513.4±50.0 °C at 760 mmHg
Melting Point219.5-220.5℃
Molecular FormulaC20H28O4
Molecular Weight332.434
Flash Point278.4±26.6 °C
Exact Mass332.198761
PSA74.60000
LogP0.88
Vapour Pressure0.0±3.0 mmHg at 25°C
Index of Refraction1.574
InChIKeyUCDVIBNDYLUWFP-MJTHGBBVSA-N
SMILESC=C1C(=O)C23C(O)CC4C(C)(C)C(=O)CCC4(C)C2CCC1C3O
Storage condition2-8°C

Synonyms

ent-7,14-Dihydroxy-16-kauren-3,15-dione
Glaucocalyxin A
(5β,7α,8α,9β,10α,13α,14R)-7,14-Dihydroxykaur-16-ene-3,15-dione
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