CAS 6452-71-7|oxprenolol

Introduction：Basic information about CAS 6452-71-7|oxprenolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. oxprenolol BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	oxprenolol
CAS Number	6452-71-7	Molecular Weight	265.34800
Density	1.0479 (rough estimate)	Boiling Point	408.57°C (rough estimate)
Molecular Formula	C₁₅H₂₃NO₃	Melting Point	78-80°
MSDS	/	Flash Point	/

Names

Name	1-(2-allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane
Synonym	More Synonyms

oxprenolol BiologicalActivity

Description	Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
Target	β-adrenoceptor:7.10 nM (Ki)
In Vitro	Oxprenolol is lipophilic[3]. Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10-3 cm/h across abdominal human skin[3].
In Vivo	Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade together with peak plasma drug levels within the normal clinical range[2]. Animal Model: Male rats (230 to 300 g body wt) of the Wistar strain[2] Dosage: 200 mg/kg Administration: Administered orally; daily for 3 weeks Result: This dosage produced effective beta-blockade.
References	[1]. T Nagatomo, et al. Binding Characteristics of ³H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7. [2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009. [3]. Modamio P, et al. A comparative in vitro study of percutaneous penetration of β-blockers in human skin. International journal of pharmaceutics, 2000, 194(2): 249-259.

Chemical & Physical Properties

Density	1.0479 (rough estimate)
Boiling Point	408.57°C (rough estimate)
Melting Point	78-80°
Molecular Formula	C₁₅H₂₃NO₃
Molecular Weight	265.34800
Exact Mass	265.16800
PSA	50.72000
LogP	2.38000
Index of Refraction	1.5000 (estimate)
InChIKey	CEMAWMOMDPGJMB-UHFFFAOYSA-N
SMILES	C=CCOc1ccccc1OCC(O)CNC(C)C

Synonyms

2-PROPANOL,1-[(1-METHYLETHYL)AMINO]-3-[2-(2-PROPEN-1-YLOXY)PHENOXY]-

Oxprenolol

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