CAS 181225-33-2|Ginsenoside F4

Introduction：Basic information about CAS 181225-33-2|Ginsenoside F4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ginsenoside F4 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Ginsenoside F4
CAS Number	181225-33-2	Molecular Weight	766.998
Density	1.3±0.1 g/cm3	Boiling Point	851.6±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₇₀O₁₂	Melting Point	/
MSDS	/	Flash Point	468.9±34.3 °C

Names

Name	β-D-Glucopyranoside, (3β,6α,12β,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)
Synonym	More Synonyms

Ginsenoside F4 BiologicalActivity

Description	Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis[1].Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues[2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>MMP
References	[1]. Chen B, et al. The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells. Nat Prod Res. 2013;27(24):2351-4. [2]. Lee JH, et al. Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. Eur J Pharmacol. 2014 Feb 5;724:145-51.

Description

Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis[1].Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues[2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>MMP

References

[1]. Chen B, et al. The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells. Nat Prod Res. 2013;27(24):2351-4.

[2]. Lee JH, et al. Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. Eur J Pharmacol. 2014 Feb 5;724:145-51.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	851.6±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₇₀O₁₂
Molecular Weight	766.998
Flash Point	468.9±34.3 °C
Exact Mass	766.486755
PSA	198.76000
LogP	8.32
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.592
InChIKey	QOMBXPYXWGTFNR-JWCBPMJDSA-N
SMILES	CC(C)=CCC=C(C)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3C(OC3OC(CO)C(O)C(O)C3OC3OC(C)C(O)C(O)C3O)CC12C
Storage condition	2-8℃

Synonyms

β-D-ribo-Hexopyranoside, (3β,6α,12β,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-, (3ξ)-

(3β,6α,12β,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl (3ξ)-2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-ribo-hexopyranoside

ginsenoside F4

(20E)-Ginsenoside F4

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